| 铂配合物与人血红细胞膜蛋白巯基的相互作用 |
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| 引用本文： | 庞茂林,张万明,安方.铂配合物与人血红细胞膜蛋白巯基的相互作用[J].河北北方学院学报(医学版),1994(1). |
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| 作者姓名： | 庞茂林 张万明 安方 |
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| 作者单位： | 张家口医学院普通化学教研室
(庞茂林，张万明)，张家口医学院普通化学教研室(安方) |
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| 摘 要： | 以巯基试剂5,5＇—二硫对硝基苯甲酸(DTNB)为试剂,分光光度法研究了人血红细胞膜蛋白巯基与顺—二氯二氨合铂(Ⅱ)(顺铂,CDDP)、反—二氯二氨合铂(Ⅱ)(反铂,TDDP),顺—二氨二水合铂(Ⅱ)(水解铂,CAAP)、顺—二碘二氨合铂(Ⅱ)(碘铂)、顺—二氨—1,1—环丁二甲酸根合铂(Ⅱ)(卡铂,CBDCA)的相互作用的速度,其结合能力为:碘铂>反铂>顺铂>水解铂>卡铂同时探讨了DTNB的光敏特性。
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| 关 键 词： | 铂配合物 红细胞膜 巯基 巯基试剂 |
THE INTERACTION OF THE PLATINUM COMPPEXES WITH SULFHYDRYL OF ERYTHROCYTE MEMBRANES |
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| Pang Maolin.THE INTERACTION OF THE PLATINUM COMPPEXES WITH SULFHYDRYL OF ERYTHROCYTE MEMBRANES[J].Journal of Hebei North University:Medical Edition,1994(1). |
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| Authors: | Pang Maolin |
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| Institution: | Pang Maolin |
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| Abstract: | The interaction of the platinum complexes with the sulfhy-dryl of erythrocyte membranes was studied by UV-spectrophotometry.We used 5,5-dithiobis (2-nitrobenzonic acid) (DTNB,Ellman'sregent) to determine the content of the sulfhydryl, The result indicated that these platinum complexes can combine with the sulfhydryl, The abilityof combination is as follows:cis-Pt (NH3)2I2>trans-Pt (NH3)2C12>cis-Pt (NH3)zCl2>cis-Pt (NH3)2(H2O)2] 2 >carboplatin It can be concluded that the combination of the platinum complexes with the sulfhydryl is related with its cell toxicity. The photosensitivityness of DTNB was also investigated |
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| Keywords: | platinum complexe erythrocyte membranes sulfhydryl DTNB |
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