Extremely high frequency of autoimmune-predisposing alleles in medieval specimens |
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| Authors: | Witas H W J?drychowska-Dańska K Zawicki P |
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| Institution: | (1) Department of Molecular Biology, Medical University of Lodz, Sporna 36/50, PL-91738 Lodz, Poland |
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| Abstract: | The precise etiology and reasons for the increase in incidence of autoimmune disorders still remain unclear, and although
both genetic and environmental factors have been proven to shape individual predisposition, it is not known which of the factors,
if not both, is responsible for the boom observed during the last decades. In order to establish whether a higher frequency
of autoimmune-predisposing alleles may explain this increase we took advantage of ancient DNA methodology to establish the
genetic predisposition, conferred by cytotoxic T lymphocyte associated antigen-4 (CTLA4) +49A/G and human leukocyte antigens (HLA) DQB1
57, in population inhabiting Poland in the Middle Ages. After successful typing of 42 individuals from a 12th∼14th’s century
archeological burial site, we found that frequencies of the predisposing alleles in the medieval population were higher than
they are at present, suggesting thus that the recently observed incidence increase results most probably from factors of other
than genetic nature.
Project (No. 3 P05E 055 25) supported by the Ministry of Education and Science of Poland |
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| Keywords: | Ancient DNA (aDNA) Autoimmunity Cytotoxic T lymphocyte associated antigen-4 (CTLA4) gene HLA DQB1 Type 1 diabetes (T1D) |
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