Toxicology and free radicals scavenging property of Tamra bhasma |
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| Authors: | N Pattanaik Ajita V Singh R S Pandey B S Singh Mohan Kumar S K Dixit Yamini B Tripathi |
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| Institution: | (1) Department of Pathology and Rasa Shastra, Institute of Medical Science, Banaras Hindu University, 221005 Varanasi;(2) Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, 221005 Varanasi, India |
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| Abstract: | Free radicals are implicated in various chronic diseases. There has always been a search for new antioxidants. In this paper
we have investigated Tamra bhasma, a metallic ayurvedic preparation. It is a time-tested medicine in Ayurveda and is in clinical
use for various ailments specifically the free radical mediated diseases. Our results show that Tamra bhasma inhibits lipid
peroxidation (LPO), prevents the rate of aerial oxidation of reduced glutathione (GSH) content and induces the activity of
superoxide dismutase (SOD) in rat liver homogenate in the bi-phasic manner. The drug was orally given for 7, 15 and 30 days
in different doses. Best protective response was found at the dose of 0.5mg/100g body weight in albino rats, although it showed
some histopathological changes at the dose of 20mg/100g body weight. The results suggest that this Ayurvedic preparation is
not merely a source of copper metal, but it is a strong anti-oxidant with no detectable adverse effect in lower doses of therapeutic
range. |
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| Keywords: | Copper antioxidant superoxide dismutase Tamra bhasma Ayurvedic metallic preparation antilipid peroxidation toxicology of metals |
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