Investigation of stressful life events in patients with systemic sclerosis |
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| Authors: | Yue Chen Ji-zhong Huang Yu Qiang Jin Wang Mao-mao Han |
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| Institution: | [1]Department of Geriatrics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China [2]Department of Surgery, Hangzhou Tongji Hospital, Hangzhou 310012, China |
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| Abstract: | Objective To assess the occurrence of stressful life events in the year before the initiation of systemic sclerosis.
Methods A consecutive series of 40 patients with systemic sclerosis (mean age (56.3±11.9) years, mean disease duration (4.3±3.1) years;
32 females and 8 males), including 28 with diffuse cutaneous scleroderma and 12 with limited cutaneous scleroderma, were evaluated.
A control group of 40 healthy subjects free of systemic sclerosis also was included. Socioeconomic status was investigated
and Paykel’s interview for recent life events (a semi-structured research interview covering 64 life events) was conducted.
Results Patients with systemic sclerosis showed higher percentages of lower education (72.5%) and working class (82.5%), and reported
more stressful life events (P<0.05), such as exits (P<0.05), undesirable events (P<0.01), and uncontrolled events (P<0.001), when compared with the control. More events that had an objective negative impact (P<0.001) were also reported in systemic sclerosis patients than in the control. These results are in accordance with a multifactorial
model of pathogenesis in systemic sclerosis.
Conclusion We reported a strong relationship between stressful life events and the initiation of systemic sclerosis. Our findings are
consistent with current understanding of the extensive links of behavioral responses to stress with neurophysiological and
biochemical processes.
Project (No. B340406052) supported by the Science and Technology Foundation of Shanghai Railway Bureau of China |
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| Keywords: | Systemic sclerosis (SSc) Life events Stress Pathogenesis |
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