Role of Oxidative Stress in Various Stages of Psoriasis |
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| Authors: | Dipali P Kadam Adinath N Suryakar Rajesh D Ankush Charushila Y Kadam Kishor H Deshpande |
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| Institution: | (1) Department of Biochemistry, Dr. V. M. Govt. Medical College, Solapur, Maharashtra, India |
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| Abstract: | Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various
exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently,
it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system
may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity
was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects)
and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant
enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects.
As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with
decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis
suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and
decreased antioxidant potential in psoriasis. |
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| Keywords: | Psoriasis Lipid peroxidation Total antioxidant status Oxidative stress Enzymatic antioxidants |
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