| Synthesis of thiadiazole-based Schiff base metal complexes and their inhibition rate to superoxide anion free radical |
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| 作者姓名： | WANG Jian-hua LV Zheng-jian XU Shi-rong |
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| 作者单位： | [1]College of Bio-engineenng, Chongqing University, Chongqing 400030, P.R. China [2]Key Lab of Biomechanics ＆ Tissue Engineenng Under the State Ministry of Education, Chongqing University, Chongqing 400030, P.R. China |
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| 基金项目： | Funded by the Natural Science Foundation of Chongqing City （[2003]7974）. |
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| 摘 要： | A new series of Schiff base ligands were synthesized by the condensation of 2-amino-5-mercaptan-l,3,4-thiadiazole and salicylaldehyde or 2,4-dihydroxybenzaldehyde and their derivatives with choroacetic acid, and further reaction with corresponding metal acetate to form metal complexes. The compositions and structures of the ligands and their complexes were characterized by elemental analysis, molar conductivities, electronic absorption spectra and infra-red spectra. Their inhibition rates to free radical, such as O2, were also tested. The results show that all of the obtained complexes display significant activities, among which the copper（Ⅱ） complexes have the best inhibitive effects.
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| 关 键 词： | 配位化合物 噻重氮 席夫碱 过氧阴离子自由基 抑制率 |
| 文章编号： | 1671-8224（2005）04-0223-06 |
| 收稿时间： | 2005-01-10 |
| 修稿时间： | 2005-06-20 |
Synthesis of thiadiazole-based Schiff base metal complexes and their inhibition rate to superoxide anion free radical |
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| WANG Jian-hua LV Zheng-jian XU Shi-rong.Synthesis of thiadiazole-based Schiff base metal complexes and their inhibition rate to superoxide anion free radical[J].Journal of Chongqing University,2005,4(4):223-228. |
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| Authors: | WANG Jian-hu LV Zheng-jian XU Shi-rong |
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| Abstract: | A new series of Schiff base ligands were synthesized by the condensation of 2-amino-5-mercaptan-1,3,4-thiadiazole and salicylaldehyde or 2,4-dihydroxybenzaldehyde and their derivatives with choroacetic acid, and further reaction with corresponding metal acetate to form metal complexes. The compositions and structures of the ligands and their complexes were characterized by elemental analysis, molar conductivities, electronic absorption spectra and infra-red spectra. Their inhibition rates to free radical, such as O2, were also tested. The results show that all of the obtained complexes display significant activities, among which the copper(II) complexes have the best inhibitive effects. |
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| Keywords: | thiadiazole schiff base coordination compounds anti-superoxide free radical activities |
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