Study of serum<Emphasis Type="Italic">Helicobacter pylori</Emphasis> soluble antigen |
| |
| Authors: | Wu Qin-dong Zhu Yong-liang |
| |
| Institution: | (1) Department of Gastroenterology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 310009 Hangzhou, China |
| |
| Abstract: | Objective: to explore a new serological method for detectingHelicobacter pylori (H. pylori) infection. Methods: Serum soluble antigen ofH. pylori was detected by using avidin-biotin ELISA technique to evaluate the status ofH. pylori infection and for comparison with rapid urease test (RUT), histologic examination and serology. Results: The sensitivity,
specificity, positive predictive value and negative predictive value were 77.46%, 91.07%, 91.67% and 76.12%, respectively.
The prevalence rate of serumH. pylori soluble antigen in 138 patients undergoing endoscopy was similar to the rate obtained by14C-UBT methods (P>0.05). Conclusions: The detection of serumH. pylori soluble antigen(HpSAg) could be used as a new serological method which is accurate, and convenient, not affected by the memorizing
reaction of serum antibody; is more sensitive, more specific and suitable for clinical diagnosis, and evaluation of eradication
and for follow-up ofH. pylori as well as for detection in children and pregnant women.
Project supported by Zhejiang Provincial Health Bureau (No. 2000A118), China |
| |
| Keywords: | Helicobacter pylori Antigen Serology |
| 本文献已被 SpringerLink 等数据库收录！ |
|
