Lipid profile in leukemia and Hodgkin's disease |
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| Authors: | P P Naik M S Ghadge A S Raste |
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| Institution: | (1) Department of Biochemistry, Tata Memorial Hospital, 5th Floor, Annexe Building, Dr. E. Borges Marg, Parel, 400012 Mumbai |
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| Abstract: | A number of epidemiologic studies has been published in recent years showing an increase risk of death from cancer in subjects
with low plasma cholesterol levels. Although several authors proposed that hypocholesterolemia is predisposing factor for
cancer development, no causative relation has been established so far and that it may be that low plasma cholesterol is secondary
to malignant disease. Hence, the present study was undertaken to examine the lipid profile in children patients with leukemia
and Hodgkin's disease in comparison with age matched controls. The study included 52 normal healthy controls and 105 patients
with leukemia and Hodgkin's disease. Lipid profile included serum cholesterol, HDL & LDL cholesterol and triglycerides. Serum
cholesterol, HDL & LDL cholesterol were found to be inversely associated with incidence of cancer, whereas triglycerides were
significantly elevated in cancer patients. The inverse association between cancer and serum cholesterol may reflect a physiological
response to early undiagnosed stages of cancer. |
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| Keywords: | Blood lipids Leukemia Hodgkin's disease |
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