| 力竭运动时阿片肽对免疫机能的作用 |
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| 引用本文： | 矫玮,佟启良,王耐勤,刘彤.力竭运动时阿片肽对免疫机能的作用[J].体育科学,2000,20(3):56-58. |
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| 作者姓名： | 矫玮 佟启良 王耐勤 刘彤 |
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| 作者单位： | 1. 北京体育大学,人体运动科学系,北京,100084
2. 北京市肿瘤研究所,北京,100034 |
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| 基金项目： | 霍英东青年教师科研基金 |
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| 摘 要： | 本题拟研究阿片肽在力竭运动时对免疫功能的影响，小鼠腹腔注射３．５ｍｇ／ｋｇ体重，注射３０ｍｉｎ手做一次性游泳力竭运动，观察脾的Ｔ淋巴细胞和Ｂ淋巴细胞转化及腹腔巨噬细胞分泌的变化，结果表明，阿征肽可以抑制Ｂ淋巴细胞的增残转化，促进Ｔ细胞的转化；力竭运动使腹腔巨噬细胞分泌白细胞介素－１水平降低，阿征肽可促进腹腔巨噬细胞分泌白细胞介素－１。实验结果提示，阿片肽在体内对不同的免疫细胞作用不同，它可以抑制Ｂ
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| 关 键 词： | 力竭运动 阿征肽 纳洛酮 免疫机能 |
| 修稿时间： | 1999-12-20 |
Effects of Opiate on the Immune Functions Induced by Exhaustive Exercise in Mice |
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| Jiao Wei et al.Effects of Opiate on the Immune Functions Induced by Exhaustive Exercise in Mice[J].China Sport Science,2000,20(3):56-58. |
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| Authors: | Jiao Wei |
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| Abstract: | The purpose of this study was to examine the changes of immune functions after cavum abdomens injection of naloxone (3.5mg/kg weight) in mice. 30 minutes after injection of opiate blocker naloxone, the mice swum to exhaustion and samples were taken from mice after exhaustive swimming. LPS induced and ConA induced lymphocyte proliferation, IL 1 production of cavum abdomen macrophage were studied in vitro. The main results by exhaustive exercise were: endogenous opiate can enhance spleen lymphocyte proliferation to ConA and reduce spleen lymphocyte proliferation to LPS, endogenous opiate can stimulate IL 1 production of cavum abdomens macrophage, endogenous opiate acts one role of repression immune function in exhausting exercise. |
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| Keywords: | fatigue immunization endorphin naloxone lymphocyte proliferation mouse |
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