Evaluation of adenosine deaminase activity and lipid peroxidation levels in diabetes mellitus |
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| Authors: | Anjali C Warrier Narasimha Y Rao Devdutta S Kulpati Tarun K Mishra Bhaskar C Kabi |
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| Institution: | 1. Department of Biochemistry, Maulana Azad Medical College and Associated Lok Nayak Jai Prakash Narayan Hospital, 110 002, New Delhi
2. Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Jai Prakash Narayan Hospital, 110 002, New Delhi
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| Abstract: | There was increase in erythrocyte lipid peroxidation and adenosine deaminase (ADA) activity in red blood cells (RBC's), white
blood cells (WBC's) and plasma, in 30 patients of confirmed diabetes mellitus, 10 each of insulin dependent diabetes mellitus
(IDDM or type I), non-insulin dependent diabetes mellitus (NIDDM or type II) and diabetes with ketoacidosis when compared
with 20 healthy individuals (controls). Glycosylated hemoglobin A1c%, plasma free fatty acid (FFA) and glycerol levels were
also elevated in all the cases when compared with controls. The increase was more in diabetic ketoacidosis group. Significant
positive correlations were seen between erythrocyte lipid peroxidation and ADA activities in RBC's, WBC's and plasma. It is
suggested that decreased tissue adenosine levels due to increase in ADA activity, is related to the severity of hyperglycemia
and lipid peroxidation in diabetes mellitus. |
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| Keywords: | Adenosine deaminase Adenosine Lipid peroxidation Hyperglycemia Diabetes mellitus |
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