Interaction of LDL and platelets in ischaemic and ischaemic risk subjects |
| |
| Authors: | Yashika Gupta V Mallika D K Srivastava |
| |
| Institution: | (1) Department of Biochemistry, G.B. Pant Hospital, 110002 New Delhi, India;(2) 5721 San Diego Street, 94530 El Cerrito, CA, USA |
| |
| Abstract: | Platelets play a vital role in the progression of atherosclerosis and thrombosis, a major cause of death worldwide. Platelets
are activated by many triggers like elevated LDL in blood resulting in aggregation and formation of plaque. The purpose of
this study was to investigate the effect of LDL and signal transduction inhibitor on the activation of platelets in Ischaemic
risk subjects. Platelets from IHD and hyperlipidemic subjects were hypersensitive to ADP, as higher levels of platelet aggregation
were observed in these groups. LDL from IHD hyperlipidemic subjects was more effective in activating platelets from any other
group. Ox-LDL was more effective in activating platelets than native-LDL as monitored by level of platelet aggregation induced
by PAF and thrombin. Calcium channel blocker, nifedipine and verapamil inhibited platelet aggregation at micromolar level.
Protein kinase inhibitor, staurosporine was effective in inhibiting ADP induced aggregation at nanomolar level. |
| |
| Keywords: | LDL ox-LDL Calcium Platelet Platelet aggregation |
| 本文献已被 SpringerLink 等数据库收录！ |
|
