Hypoglycaemic, hypolipidemic and antioxidant properties of tulsi (Ocimum sanctum linn) on streptozotocin induced diabetes in rats |
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| Authors: | Eshrat Halim M A Hussain Kaiser Jamil Mala Rao |
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| Institution: | (1) National Chemical Laboratory, 411008 Pune;(2) Indian Institute of Chemical Technology, 500007 Hyderabad |
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| Abstract: | Effect of oral administration of 200 mg/Kg body weight of the aqueous extract ofOcimum sanctum (Tulsi) mixed with diet for eight weeks to diabetic (streptozotocin induced) rats was studied. There was significant reduction
in fasting blood glucose, serum lipid profile, lipid peroxidation products, (LPO) and improvement in glucose tolerance. The
aqueous extract also decreased LPO formation (thiobarbituric acid reactive substances TBARS) and increased antioxidant enzymes
superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione transferase (GT) and one antioxidant
reduced glutathione (GSH) in plasma and rat liver, lung, kidney and brain. The decrease in TBARS and increase in GSH, SOD,
CAT, GPX, and GT clearly shows the antioxidant property ofOcimum sanctum. |
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| Keywords: | Ocimum sanctum diabetes mellitus hypoglycemic effect hypolipidemic effect lipid peroxidation antioxidants |
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