| 吗啡、食物诱导的条件性位置偏爱获得与保持的比较 |
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| 引用本文： | 李勇辉,郑希耕,鞠平,刘杰,杨晓燕,隋南.吗啡、食物诱导的条件性位置偏爱获得与保持的比较[J].中国科学院研究生院学报,2005,22(4):467-471. |
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| 作者姓名： | 李勇辉 郑希耕 鞠平 刘杰 杨晓燕 隋南 |
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| 作者单位： | 1. 中国科学院心理研究所,中国科学院心理健康重点实验室,北京,100101;中国科学院研究生院,北京,100049
2. 中国科学院心理研究所,中国科学院心理健康重点实验室,北京,100101 |
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| 基金项目： | 国家重点基础研究发展计划 ( 973计划,2 0 03CB5 15 40 4)，国家自然科学基金重点项目( 3 0 2 3 0 13 0 )，中国科学院知识创新工程项目 (KSCX2 SW 2 0 4 0 2 )资助 |
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| 摘 要： | 应用条件性位置偏爱模型研究了大鼠吗啡与食物条件性位置偏爱(CPP)获得与保持的差异,结果发现,经过6轮训练后吗啡与食物都形成相同程度的条件性位置偏爱;但5次熄灭测试后吗啡的条件性位置偏爱程度没有明显的消退,而食物的条件性位置偏爱明显消退.表明经过充分训练后吗啡与食物奖赏记忆的获得没有显著差异,但吗啡奖赏记忆保持时间更长.成瘾药物所产生的奖赏记忆的长久性可能是成瘾长期性的重要原因之一
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| 关 键 词： | 吗啡 食物 条件性位置偏爱 获得 记忆保持 |
| 文章编号： | 1002-1175(2005)04-0467-05 |
| 修稿时间： | 2004年6月9日 |
Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference |
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| LI Yong-hui,ZHENG Xi-Geng,Ju Ping,LIU Jie,YANG Xiao-Yan,SUI Nan.Comparison between Acquisition and Retention of Morphine and Food-Induced Conditioned Place Preference[J].Journal of the Graduate School of the Chinese Academy of Sciences,2005,22(4):467-471. |
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| Authors: | LI Yong-hui ZHENG Xi-Geng Ju Ping LIU Jie YANG Xiao-Yan SUI Nan |
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| Institution: | LI Yong-Hui 1,2 ZHENG Xi-Geng 1 JU Ping 1,2 LIU Jie 1,2 YANG Xiao-Yan 1 SUI Nan 1 |
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| Abstract: | To confirm the hypothesis that persistence of addiction is caused by reward-related memory of addictive drugs. 24 rats, in food restriction, were trained in biased conditioned place preference procedure. Both morphine and food established conditioned place preference at the same level after 6 sessions training. Food-induced CPP was extinct, while morphine-induced CPP was preserved after 4 retests. It is suggested acquisition of conditioned place preference produced by morphine and food is similar, however, morphine CPP is maintained longer. The inveterate reward-related memory induced by addictive drugs is a major factor for the persistence of addiction. |
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| Keywords: | morphine food conditioned place preference acquisition retention |
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