| 2,4-二甲氧基苯甲醛的合成 |
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| 引用本文： | 韦立红,崔凤侠,郑建军,杜小鹃,尹志锋,赵桂琴,郭春燕.2,4-二甲氧基苯甲醛的合成[J].河北北方学院学报(医学版),2001,18(4):26-27. |
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| 作者姓名： | 韦立红 崔凤侠 郑建军 杜小鹃 尹志锋 赵桂琴 郭春燕 |
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| 作者单位： | 1. 承德医学院化学教研室,067000
2. 张家口医学院化学教研室,075000 |
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| 摘 要： | 目的研究2,4-二甲氧基苯甲醛的合成.方法以间苯二酚为原料,用Gatternann-Adams法合成2,4-二羟基苯甲醛,再经硫酸二甲酯甲基化.结果总收率65.6%.结论在2,4-二羟基苯甲醛的甲基化的反应中,我们改变了传统的以氢氧化钠为碱,以水为溶剂的方法,收率有较大提高.
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| 关 键 词： | 2 4-二甲氧基苯甲醛 2 4-二羟基苯甲醛 合成 |
| 文章编号： | 1005-8796(2001)04-026-02 |
Syntheses of 2, 4-Dimethoxylbenzaldehyde |
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| Wei Lihong,Zheng Jianjun,Cui Fengxia et al.Syntheses of 2, 4-Dimethoxylbenzaldehyde[J].Journal of Hebei North University:Medical Edition,2001,18(4):26-27. |
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| Authors: | Wei Lihong Zheng Jianjun Cui Fengxia |
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| Institution: | Wei Lihong,Zheng Jianjun,Cui Fengxia et al Department of Chemistry,Chengde Medical College,Chengde 067000,China |
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| Abstract: | Objective: To modify the synthesis method of 2, 4 - Dimethoxylbenzaldehyde. Methods: 2, 4 - Dimethoxylbenzaldehyde was synthesized by methylation of 2, 4 - Dihydroxyl-benzaldehyde with dimethyl sulfate, derived from o - diphenol, by means of Gattemann -Adams. Results: The total yield was 65.6% . Conclusion: 2,4 - Dimethoxylbenzaldehyde Couldbe synthesized by methylation of 2, 4 - Dihydroxylbenzaldehyde with dimethyl sulfate instead of sodium hydroxide and distilled water. The tolal yield by this new method has been much improved compared with the old one. |
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| Keywords: | 2 4- Dimethoxylbenzaldehyde 2 4- Dihydroxylbenzaldchyde Synthesis |
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