| 实验性兔脑血管痉挛血清MMP-9及VEGF的变化研究 |
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| 引用本文： | 高宝山,汪大庆.实验性兔脑血管痉挛血清MMP-9及VEGF的变化研究[J].大连大学学报,2009,30(3):95-102. |
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| 作者姓名： | 高宝山 汪大庆 |
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| 作者单位： | 1. 大连大学附属中山医院,辽宁大连,116001
2. 山东省肥城市中医院,山东肥城,271600 |
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| 摘 要： | 观察血清基质金属蛋白酶-9（MMP-9）及血管内皮生长因子（VEGF）在实验性新西兰白兔蛛网膜下腔出血后的浓度变化，探讨它们与脑血管痉挛发生、发展及转归过程的关系，为临床诊断及治疗提供理论依据。实验结果表明血清MMP-9及VEGF的浓度变化可以作为预测蛛网膜下腔出血后脑血管痉挛的发作、判断其发展及预后的参考指标之一，为临床诊断与治疗提供依据。MMP-9及VEGF参与了蛛网膜下腔出血后的病理生理过程，与迟发性脑血管痉挛的发病机制有密切关系。
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| 关 键 词： | 基质金属蛋白酶-9 血管内皮生长因子 脑血管痉挛 |
The experimental study of serum matrix MMP-9 and VEGF in rabbit with cerebral vasospasm after subarachnoid hemorrhage |
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| GAO Bao-shan,WANG Da-qing.The experimental study of serum matrix MMP-9 and VEGF in rabbit with cerebral vasospasm after subarachnoid hemorrhage[J].Journal of Dalian University,2009,30(3):95-102. |
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| Authors: | GAO Bao-shan WANG Da-qing |
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| Institution: | GAO Bao - shan , WANG Da - qing (1. Affiliated Zbongshan Hospital of Dalian Vniversity , Dalian 116001 China; 2. Hospital of Chinese Medicine, FeiCheng 271600 China ) |
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| Abstract: | Observe the level of serum Matrix Metalloproteinase-9(MMP-9)and Vascular Endothelial Growth Factor(VEGF) in experiment after cerebral vasospasm(CVS) with subarachnoid hemorrhage(SAH) in New Zealand rabbit model,and discuss the relation of serum MMP-9 and VEGF after SAH,then provide the basic theory for clinical diagnosis and treatment.The Results showed that there was little change of serum MMP-9 and VEGF in the control group(p>0.05).But in the model group,the level of them increased progressively at the 24th hour after operation,the peak at the 5th-7th day,and decreasingly till the normal state at 14th day(p<0.05).It was found that the change of the level of MMP-9 and VEGF could be used to predict the onset,progress and the prognosis of CVS after SAH,and provided the basic theory for the clinical diagnoses and treatment.MMP-9 and VEGF participated in the pathophysiological process of SAH,and was correlated with delayed cerebral vasospasm. |
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| Keywords: | matrix metalloproteinase-9 vascular endothelial growth factor cerebral vasospasm |
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