| 魔芋葡甘聚糖/聚乙烯吡咯烷酮水凝胶的制备及缓释性能研究 |
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| 引用本文： | 陈彦青,刘昌华,陈建光,戴勋,郭晓利.魔芋葡甘聚糖/聚乙烯吡咯烷酮水凝胶的制备及缓释性能研究[J].宜宾学院学报,2008,8(6). |
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| 作者姓名： | 陈彦青 刘昌华 陈建光 戴勋 郭晓利 |
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| 作者单位： | 西南大学化学化工学院,重庆400715;重庆高校魔芋资源利用工程研究中心,重庆400715 |
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| 摘 要： | 以魔芋葡甘聚糖（KGM）和聚乙烯吡咯烷酮（PVP）为原料，戊二醛（GA）为交联剂，合成了KGM／PVP半互穿网络水凝胶。通过红外光谱、X-衍射、SEM扫描电镜对水凝胶的结构进行了袁征，并且研究了KGM与PVP质量比、交联剂含量对水凝胶的溶胀度影响。在p14=2．2和pH=7．4条件下分别研究了交联度对溶胀动力学特性的影响，以及载药凝胶的体外释放行为。实验结果表明，KGM与PVP质量比对该凝胶的溶胀性能有一定的影响：KGM：PVP为1：1时，凝胶的溶胀度最大；随着交联剂含量的增加，凝胶的溶胀度、溶胀速率、药物的释放速率均逐渐降低；凝胶在pH=2．2时的溶胀度较高，溶胀速率、药物的释放速率均较快。
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| 关 键 词： | 魔芋葡甘聚糖 水凝胶 缓释 溶胀动力学 |
The Preparation and Characterization of Konjac Glucomannan/Polyvinylpyrrolidone Hydrogel for Controlled Release in Vitro |
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| Authors: | CHEN Yan-qing LIU Chang-hua CHEN Jian-guang DAI Xun GUO Xiao-li |
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| Institution: | CHEN Yan-qing1,2,LIU Chang-hua1,CHEN Jian-guang1,DAI Xun1,GUO Xiao-li1,2 (1.College of Chemistry , Chemical Engineering,Southwest University,Chongqing 400715,China,2.Engineering Center of Chongqing Universities of Konjac Resources Research,China) |
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| Abstract: | A semi-interpenetrating polymer networks hydrogel was prepared with Konjac Glucomannan and polyvinylpyrrolidone using glutaraldehyde as crosslinking agent.The structure of the semi-IPN hydrogel was studied by Fourier transform infrared spectroscopy,X-ray diffraction and scanning electron microscopy.The effect of the mass ratio of Konjac Glucomanna to polyvinylpyrrolidone and the content of crosslinking agent on the swelling ratio was investigated.Meanwhile,the effect of the degree of the hydrogel crosslinki... |
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| Keywords: | Konjac Glucomannan Hydrogel Controlled Release Swelling Kinetics |
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