Raised serum homocysteine levels in patients of coronary artery disease and the effect of vitamin B12 and folate on its concentration |
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| Authors: | R Abraham M Joseph John R Calton J Dhanoa |
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| Institution: | (1) Dept of Biochemistry, Christian Medical College, 141008 Ludhiana, Punjab;(2) Dept of Medicine, Christian Medical College, 141008 Ludhiana, Punjab;(3) Dept of Cardiology, Christian Medical College, 141008 Ludhiana, Punjab;(4) Department of Biochemistry, Pondicherry Institute of Medical Sciences, 605014 Pondicherry |
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| Abstract: | Homocysteine(Hcy) has been implicated as a novel risk factor of Coronary Artery Disease (CAD) among Asian Indians, but many
studies done in India failed to reveal any direct correlation. It has also been reported that Folic acid and Vitamin B12 levels
inversely affect serum levels of homocysteine. In this study, we looked at the levels of homocysteine among patients with
CAD. The effect of Vitamin B12, Folate and other risk factors on homocysteine levels were also evaluated. Mean homocysteine
levels in cases (22.81±13.9, n=70) were significantly higher (p=<0.001) than the controls (7.77±7.3, n=70). However no statistically
significant correlation could be deduced between homocysteine Vitamin B12, and Folate. Cumulative analysis have indicated
an increase in homocysteine levels among patients with CAD with every additional risk factor. |
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| Keywords: | Homocysteine Coronary Artery Disease |
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