| 运动性疲劳影响大鼠学习记忆功能和脑组织内Tau的表达 |
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| 引用本文： | 王太林.运动性疲劳影响大鼠学习记忆功能和脑组织内Tau的表达[J].北京体育大学学报,2011,34(6):54-56. |
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| 作者姓名： | 王太林 |
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| 作者单位： | 中北大学体育与艺术学院; |
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| 基金项目： | 国家自然科学基金资助项目:运动诱导c-fos原癌基因在大鼠脑内的表达及靶基因研究(30671019) |
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| 摘 要： | 目的:建立大鼠运动性疲劳模型,通过免疫组织化学法检测大鼠大脑皮层和海马CA1区内Tau蛋白的分布与表达,探讨其在运动性疲劳致大鼠学习记忆障碍发病机理中的作用。方法:成年雄性Wistar大鼠随机平均分为对照组、疲劳即刻组和疲劳恢复90 min组。疲劳即刻组和疲劳恢复90 min组大鼠进行十天游泳运动,每天运动至力竭,对照组大鼠不加干预。运用避暗穿梭实验检测大鼠学习记忆功能损伤情况,免疫组织化学法检测大脑皮层和海马CA1区Tau蛋白分布及表达,并测定Tau蛋白免疫阳性细胞的积分光密度值(IOD)。结果:疲劳即刻组和疲劳恢复90 min组大鼠学习记忆功能有不同程度损伤,其大脑皮层和海马CA1区Tau蛋白表达较对照组上调(P<0.05)。结论:运动性疲劳致大鼠学习记忆功能损伤可能与大鼠大脑皮层和海马内Tau蛋白的表达变化相关。
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| 关 键 词： | 运动性疲劳 学习 记忆 Tau |
Effects of Exercise-induced Fatigue on Rat Learning and Memory Ability and Expressions of Tau in the Brain |
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| WANG Tai-lin.Effects of Exercise-induced Fatigue on Rat Learning and Memory Ability and Expressions of Tau in the Brain[J].Journal of Beijing Sport University,2011,34(6):54-56. |
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| Authors: | WANG Tai-lin |
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| Institution: | WANG Tai-lin(Sports and Art Institute,North University of China,Taiyuan 030051,Shanxi China) |
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| Abstract: | Objective: Through establishing the rat model of exercise-induced fatigue,the paper detected the distribution and expression of Tau in the cerebral cortex and hippocampus CA1,and explored the role of Tau in fatigue-induced learning and memory disorder.Methods: Adult male SD rats were randomly divided into control group,10-day fatigue group and recovery 90min group.Rats in 10-day fatigue group and recovery 90min group exercised to exhausted by swimming for 10 days,and those in control group didn't exercise.D... |
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| Keywords: | exercise-induced fatigue learning memory Tau |
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