Abstract: | Bioconversions of lipophilic compounds are currently attracting much interest in both the academic and the industrial world. To carry out these conversions effectively, it is essential to introduce water-miscible organic solvents into the reaction Systems or to use water-containing organic solvents as reaction solvents in order to improve the poor solubility of substrates in aqueous solutions. However, biocatalysts are in general liable to lose their activity in the presence of organic solvents. It is expected that enzyme immobilization will be the most general and promising means of reconciling these opposing demands. |