| 运动对ApoE基因敲除鼠动脉粥样硬化形成的干预作用及机制 |
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| 引用本文： | 袁凌燕,陆爱云.运动对ApoE基因敲除鼠动脉粥样硬化形成的干预作用及机制[J].上海体育学院学报,2006,30(5):56-61. |
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| 作者姓名： | 袁凌燕 陆爱云 |
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| 作者单位： | 上海体育学院,运动科学系,上海,200438 |
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| 摘 要： | 探讨运动对动脉粥样硬化形成的延缓作用及抗氧化作用途径、脂代谢途径,以ApoE建立动脉粥样硬化(AS)模型,观察有氧运动对ApoE-/-小鼠主动脉斑块面积、血脂、血氧化低密度脂蛋白、肝MDA、肝SOD的影响。结果:ApoE-/-小鼠形成明显斑块,存在氧化水平的升高和血脂紊乱,运动可使斑块面积减少,使ApoE-/-小鼠血oxldl、肝MDA降低,肝SOD升高,但运动没有影响ApoE-/-小鼠的血脂水平,且运动均不影响正常状态,即C57小鼠的脂代谢和氧化水平。结论:运动可通过调节机体的氧化抗氧化水平,发挥抗动脉粥样硬化的作用,可能独立于降血脂途径。
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| 关 键 词： | 动脉粥样硬化 运动 ApoE基因敲除小鼠 氧化/抗氧化 |
| 文章编号： | 1000-5498（2006）05-0056-06 |
| 收稿时间： | 2006-05-06 |
| 修稿时间： | 2006-06-27 |
Effect of Exercise on Interfering Formation of Atherogenesis in ApoE-deficient Mice and Its Mechanism |
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| YUAN Lin-yan,LU Ai-yun.Effect of Exercise on Interfering Formation of Atherogenesis in ApoE-deficient Mice and Its Mechanism[J].Journal of Shanghai Physical Education Institute,2006,30(5):56-61. |
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| Authors: | YUAN Lin-yan LU Ai-yun |
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| Institution: | Sports Science Dept. , Shanghai University of Sport, Shanghai, 200438, China |
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| Abstract: | It inquired into the effect of exercise on postponing the formation of atherogenesis and the channel of antioxidation and lipid metabolism,and established a atherosclerotic model to observe the effect of aerobic exercise on the area of aortic plaque,blood lipid,blood oxidative low-density lipid protein and MDA and SOD of livers of ApoE mice.The results reveal that as for ApoE mice,there exist a formation of remarkable plaque,a rise of oxidative level and the disorder of blood lipid;exercise can reduce the area of plaque and make ApoE mice's blood oxidative low-density lipid protein and MDA of liver decrease,and SOD of liver rise,but it hasn't affected their blood lipid and normality,i.e.lipid metabolism and oxidative level.The conclusions are as follows: exercise can play a role in anti-atherogenesis by the aid of regulating oxidation and anti-oxidative level of body,which is probably independent in the channel of reducing blood lipid. |
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| Keywords: | atherogenesis exercise ApoE knock-out mice oxidation/anti-oxidation |
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