| 恩诺沙星缓释注射液的制备及其缓释性能评价 |
| |
| 引用本文： | 任瑾,方正杰.恩诺沙星缓释注射液的制备及其缓释性能评价[J].中国科技信息,2012(13):130-131. |
| |
| 作者姓名： | 任瑾 方正杰 |
| |
| 作者单位： | 1. 徐州医学院药学院,江苏省徐州市,221004
2. 徐州市产品质量监督检验所食品及农产品检验中心,江苏省徐州市,221000 |
| |
| 基金项目： | 徐州医学院药学院院长人才专项科研启动项目 |
| |
| 摘 要： | 目的]制备恩诺沙星缓释注射液,并对其缓释性能进行评价。方法]采用分散法制备恩诺沙星缓释注射液,考察制剂的沉降体积比,重新分散性,通针性,pH值和渗透压等各项质量指标,通过体外释放试验和家兔体内药动学实验评价制剂的缓释性能。结果]制备的恩诺沙星缓释注射液稳定,具有良好的通针性,pH约为7.04,渗透压约为0.267osml/kg。体外试验中,恩诺沙星缓释注射液在0.5h的累积释放率仅为20%,直至12h累积释放率才达到80.2%。恩诺沙星缓释注射液主要的药物动力学参数是:清除率CL为1081.561±267.35 ml!h-1,Tmax为4h,体内平均滞留时间MRT为34.271±9.316 h。结论]制备的恩诺沙星缓释注射液符合注射剂的要求,体内外试验均表明制剂具有一定的缓释效果。
|
| 关 键 词： | 恩诺沙星 缓释 注射 |
Preparation of enrofloxacin sustained-release injection and evaluation of its sustained-release properties |
| |
| Ren Jin
,
Fang Zhengjie.Preparation of enrofloxacin sustained-release injection and evaluation of its sustained-release properties[J].CHINA SCIENCE AND TECHNOLOGY INFORMATION,2012(13):130-131. |
| |
| Authors: | Ren Jin Fang Zhengjie |
| |
| Institution: | 1.Department of Pharmacy,Xuzhou Medical College,Xuzhou,221004,China 2.Department of Food and Agriculture Products Inspection,Xuzhou Production Quality Supervision and Inspection Center,Xuzhou,221000,China |
| |
| Abstract: | Objectiv]To prepare enrofloxacin sustained-release injection,then evaluate its sustained-release properties.Method]The enrofloxacin sustained-release injection is prepared by grinding.The quality of the preparation is evaluated from the following aspects: the sedimentation rate,the redispersion,the ability the preparation through the needle,the pH value,and the osmotic pressure.The sustained-release properties of the preparation is investigated by in vitro release test and in vivo pharmacokinetic behavior.Result]The enrofloxacin sustained-release injection was stable and had good ability through the needle,the pH was 7.04,the osmotic pressure was 0.267 osml/kg.In the in vitro test,enrofloxacin sustained-release injection in the 0.5h release only 20%,and reach 80.2% up to 12h,The pharmacokinetic parameters of enrofloxacin sustained-release injection were showed as follows: The CL was 1081.561±267.35 ml?h-1,The Tmax was 4h,MRT was 34.271±9.316 h.Conclusion] The quality of enrofloxacin sustained-release injection consistent with requirements of injections.And the preparation had obvious sustained-release effect. |
| |
| Keywords: | Enrofloxacin Sustained-release Injecion |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
