Evaluation of the radioprotective effect of turmeric extract and vitamin E in mice exposed to therapeutic dose of radioiodine |
| |
Authors: | Uma S Bhartiya Yogita S Raut Lebana J Joseph Rohini W Hawaldar Badanidiyoor S Rao |
| |
Institution: | (1) Radiation Medicine Centre, Biomedical Group, BARC, C/O Tata Memorial Hospital Annexe, Parel, Mumbai, 400 012, India;(2) Clinical Research Secretariat, Tata Memorial Hospital, Parel, Mumbai, 400 012, India;(3) Radiological Physics & Advisory Division, BARC, Trombay, Mumbai, 400 074, India;(4) Radiation Medicine Centre Biomedical Group, Bhabha Atomic Research Centre, C/O Tata Memorial Hospital Annexe, Parel, Mumbai, 400 012, India |
| |
Abstract: | The aim of this study was to evaluate the radioprotective effect of turmeric extract (40 mg/kg body weight) and vitamin E
(α- tocopherol acetate, 400 IU/kg body weight) supplementation on lipid peroxidation, reduced glutathione and antioxidant
defense enzymes in various organs like liver, kidney and salivary glands at 24 h in adult Swiss mice. 131Iodine exposure significantly increased lipid peroxidation in kidney and salivary glands in comparison to control animals.
Pre supplementation with turmeric extract for 15 days showed significant lowering of lipid peroxidation in kidney. On the
other hand vitamin E pre supplementation showed marked reduction in lipid peroxidation in salivary glands. Reduced glutathione
levels decreased significantly in liver after radiation exposure. However, pre supplementation with turmeric extract and vitamin
E did not improve glutathione levels in liver. In conclusion, we have observed differential radioprotective effect of turmeric
extract and vitamin E in kidney and salivary glands. However, Vitamin E seems to offer better radioprotection for salivary
glands which is known to be the major site of cellular destruction after radioiodine therapy in patients. |
| |
Keywords: | Turmeric extract Vitamin E 131Iodine Lipid peroxidation Antioxidant enzymes |
本文献已被 SpringerLink 等数据库收录! |
|