| 短期和长期运动预适应对大鼠血液和心脏降钙素基因相关肽的影响 |
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| 引用本文： | 孙晓娟,潘珊珊.短期和长期运动预适应对大鼠血液和心脏降钙素基因相关肽的影响[J].体育科学,2010,30(5). |
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| 作者姓名： | 孙晓娟 潘珊珊 |
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| 作者单位： | 1. 上海体育学院运动科学学院,上海200438;咸阳师范学院体育系,陕西,咸阳,712000
2. 上海体育学院运动科学学院,上海,200438 |
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| 基金项目： | 国家自然科学基金，上海市科学技术委员会资助项目 |
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| 摘 要： | 目的:探讨短期和长期运动预适应对大鼠血液和心脏降钙素基因相关肽(calcitonin gene-related peptide,CGRP)的影响及其对心肌保护的作用机制;方法:健康雄性SD大鼠75只,随机分为对照组(C组)、3天运动预适应组(3 d EP组)和3周运动预适应组(3周 EP组).3d EP组和3周 EP组分别进行3天和3周的间歇跑台训练建立短期和长期运动预适应动物模型.用酶联免疫法检测血清CGRP含量的变化,用western blot方法和免疫组织化学方法检测心脏CGRP定量和定位表达的变化;结果:与C组比较,3 d EP组血清OGRP含量变化不明显,3周EP组血清CGRP含量明显升高(P<0.05);与C组比较,3 d EP 组心脏CGRP 表达明显减少,OGRP 免疫反应阳性表达面积和平均光密度明显降低(P<0.05),3周EP组心脏CGRP 表达变化不明显,CGRP免疫反应阳性表达面积和平均光密度无明显变化;结论:短期运动预适应使心脏CGRP 表达下降,提示短期运动预适应可促进心脏CGRP的释放,对心肌产生保护作用;长期运动预适应使血清CGRP水平升高,提示长期运动预适应可提高机体CGRP的释放水平,对心肌产生保护作用.
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| 关 键 词： | 运动预适应 降钙素基因相关肽 血液 心脏 鼠 动物实验 |
Effects of Exercise Preconditioning on Calcitonin Gene-Related Peptide in the Blood and Heart of Rats |
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| SUN Xiao-iuan,PAN Shan-shan.Effects of Exercise Preconditioning on Calcitonin Gene-Related Peptide in the Blood and Heart of Rats[J].China Sport Science,2010,30(5). |
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| Authors: | SUN Xiao-iuan PAN Shan-shan |
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| Institution: | SUN Xiao-juan1,2,PAN Shan-shan11.Shanghai University of Sport,Shanghai 200438,China,2.Xianyang Normal University,Xianyang 712000,China. |
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| Abstract: | Objective:The effects of short-term and long-term exercise preconditioning on calcitonin gene-related peptide (CGRP) in the blood and heart of rats and the mechanism of cardioprotection were studied.Method:Seventy five healthy male SD rats were randomly divided into control group (C),3 days (3 d EP) and 3 weeks (3 w EP) exercise preconditioning groups.3 d EP and 3 w EP groups performed 3 days and 3 weeks interval treadmill exercise respectively in order to establish short-term and long-term exercise precond... |
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| Keywords: | exercise preconditioning calcitonin gene-related peptide blood heart rat |
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