Effect of water extract of <Emphasis Type="Italic">Trichosanthes dioica</Emphasis> fruits in streptozotocin induced diabetic rats |
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| Authors: | Prashant Kumar Rai Dolly Jaiswal Devendra K Rai Bechan Sharma Geeta Watal |
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| Institution: | (1) Alternative Therapeutics Unit, Drug Discovery & Development Division,. Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211002, India;(2) Biochemistry, University of Allahabad, Allahabad, 211002, India;(3) Alternative Therapeutics Unit, Drug Discovery & Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211002, India |
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| Abstract: | In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of
1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino
transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein
and body weight was increased. No toxic effect was observed during LD50. Our study suggests that further detailed toxicity
studies and mechanism of action of T. dioica would be useful for undertaking human trials. |
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| Keywords: | Antidiabetic effect Hepatoprotective Trichosanthes dioica |
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