Evaluating role of oxidative stress in determining the pathogenesis of falciparum malaria induced acute renal failure |
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| Authors: | Rachita Nanda Pramila K Mishra U K Das S B Rout P C Mohapatra A Panda |
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| Institution: | (1) Department of Biochemistry, SCB Medical College Hospital, Cuttack;(2) Department of Nephrology, SCB Medical College Hospital, Cuttack |
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| Abstract: | Serum malondialdehyde was measured in sixty-one falciparum malaria cases, which include thirty uncomplicated, and thirty-one
complicated with acute renal failure. Twenty-six healthy individuals were also studied as controls. Serum malondialdehyde
level was found to be significantly elevated in falciparum malaria induced acute renal failure cases when compared with uncomplicated
falciparum malaria (p<0.001) and healthy controls (p<0.001). A positive correlation with the raised urea, creatinine and bilirubin
levels were significant (r=0.62, p<0.025; r=0.65, p<0.05 and r=0.72, p<0.001 respectively) indicating the severity of complication
with rise of lipid peroxides in falciparum malaria induced acute renal failure cases. |
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| Keywords: | Acute renal failure Falciparum malaria Reactive oxygen species Malondialdehyde |
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