| 昆虫壳聚糖对运动训练大鼠肝脏抗氧化酶系与SOD基因表达的影响 |
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| 引用本文： | 高颖晖,周万红,曹军,王敦.昆虫壳聚糖对运动训练大鼠肝脏抗氧化酶系与SOD基因表达的影响[J].体育科学,2011,31(5):75-78. |
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| 作者姓名： | 高颖晖 周万红 曹军 王敦 |
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| 作者单位： | 西北农林科技大学,陕西,杨凌,712100 |
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| 基金项目： | 国家自然科学基金项目资助 |
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| 摘 要： | 目的:报道了补充虫源壳聚糖对大鼠肝脏抗氧化酶系和SOD基因表达影响的研究结果。方法:对大负荷游泳训练大鼠补充剂量分别为各组平均体重的0.5 g/kg、1.0 g/kg和2.0 g/kg的虫源壳聚糖,在8周大负荷训练结束后测定肝脏抗氧化酶系的活性,并分析不同处理组动物肝脏SOD基因表达水平差异。结果:补充虫源壳聚糖能够显著提高抗氧化酶系活性,虫源壳聚糖0.5 g/kg补充组与单纯大负荷运动组相比,SOD、CAT和GSH-Px酶活性显著升高(P<0.05);虫源壳聚糖1.0 g/kg和2.0 g/kg补充组与单纯大负荷运动组相比:SOD、CAT和GSH-Px酶活性升高极为显著(P<0.01)。MDA含量在不同水平虫源壳聚糖补充组均显著低于单纯大负荷运动组(P<0.01)。对SOD基因表达分析结果显示,SOD酶活性的升高与其基因表达水平提高呈正相关。结论:补充虫源壳聚糖有助于提高训练大鼠的运动肝脏抗氧化酶系活性,活性的提高与相关编码基因的表达水平提高有关。
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| 关 键 词： | 虫源壳聚糖 鼠 动物实验 肝脏抗氧化酶系 SOD基因 表达水平 |
Effects of Insect Chitosan on Antioxidant Enzymes and SOD Gene Expression in Liver of Exercise Rats |
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| GAO Ying-hui,ZHOU Wan-hong,CAO Jun,WANG Dun.Effects of Insect Chitosan on Antioxidant Enzymes and SOD Gene Expression in Liver of Exercise Rats[J].China Sport Science,2011,31(5):75-78. |
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| Authors: | GAO Ying-hui ZHOU Wan-hong CAO Jun WANG Dun |
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| Institution: | GAO Ying-hui,ZHOU Wan-hong,CAO Jun,WANG Dun Northwest A&F University,Yangling 712100,China. |
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| Abstract: | The effects of chitosan on antioxidant enzymes and CuSOD gene expression level in rat liver were analyzed in this study.The chitosan were supplemented to rats that were given swimming training at three dose levels 0.5 g/kg,1.0 g/kg and 2.0 g/kg.The activities of antioxidant enzymes and CuSOD gene expression level in rat liver were measured after eight weeks acute exercise.The activities of antioxidant enzymes were all increased among chitosan supplemented groups compared to non-supplemented exercise rats.SO... |
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| Keywords: | insect chitosan rat antioxidant enzymes in liver SOD gene expression level |
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