Role of heat stable fraction of alkaline phosphatase as an adjunct to ca 125 in monitoring patients of epithelial ovarian carcinoma |
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| Authors: | P K Nigam A Jain P Goyal R Chitra |
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| Institution: | (1) Dept. of Biochemistry, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India;(2) Dept. of Obstetrics and Gynecology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India;(3) Dr. Lal PathLabs. Pvt. Ltd., ‘Eskay House’, 54, Hanuman Road, 110 001 New Delhi |
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| Abstract: | Heat stable fraction (HSF) of alkaline phosphatase (ALP) was evaluated as an adjunct to CA 125 as a tumour marker for epithelial
ovarian cancer in a follow-up study. In our study group 63.4% of patients had elevated HSF levels (≥10U/L) and 93.3% had elevated
CA 125 levels (>35U/mL). The sensitivity of CA 125 and HSF was 93.3% and 63.3% respectively. The decline in the activity of
HSF, over the pre-op levels was highly significant after the first (p=0.001) chemotherapy cycle and significant after the
second and third cycles (p<0.029). Thereafter, HSF activity was almost undetectable. The decrease in CA 125 levels over the
pre-op levels was significant after the first, second, third (p<0.001) and fourth (p<0.034) chemotherapy cycle. HSF can be
used alone or as an adjunct to CA 125 in screening and monitoring patients of ovarian carcinoma especially in remote areas
where sophisticated facilities are not available and in patients in which CA 125 levels are not raised preoperatively. |
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| Keywords: | CA 125 Heat stable fraction of ALP Ovarian cancer PLAP Tumour marker |
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