Lack of precision in HbA1c values on variant II in cases of hemoglobin Q India |
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| Authors: | P K Nigam S Sharma R Sareen V Paul A Lal |
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| Institution: | (1) Dr Lal PathLabs Pvt Ltd, ‘ESKAY HOUSE’, 54, Hanuman Road, 110001 New Delhi, India |
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| Abstract: | This study was carried out to check the precision of HbA1c values on Bio-Rad Variant II in cases of a rare hemoglobin variant Q India. The study was carried out over a three month
period on samples collected for HbA1c estimation. Seven out of eleven patients showed variable results of HbA1c with a very high and unacceptable intraday mean coefficient of variation (CV) of 9.93%. We conclude, that the results of
HbA1c on Variant II can not be reported without adversely affecting HbA1c as a marker of long-term glycemic control in patients who have hemoglobin Q India. The HbA1c value of these patients needs to be assessed by a different instrument/method or the glycemic control be monitored by an
alternate test like serum Fructosamine. |
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| Keywords: | HbA1c precision variant hemoglobin diabetes mellitus |
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