| 酮洛芬骨架缓释片相对生物利用度研究 |
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| 引用本文： | 林舒,周静,徐伟,沙玫.酮洛芬骨架缓释片相对生物利用度研究[J].泉州师范学院学报,2010,28(2):66-69. |
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| 作者姓名： | 林舒 周静 徐伟 沙玫 |
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| 作者单位： | 1. 福建中医学院药学系,福建,福州,350108
2. 四川大学华西药学院,四川,成都,610041 |
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| 基金项目： | 福建省科技厅重点项目 |
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| 摘 要： | 采用高效液相色谱法,以布洛芬为内标,对24 h酮洛芬骨架缓释片试验制剂以24名健康志愿者进行多剂量人体相对生物利用度试验.结果表明,试验制剂具有明显的缓释药动学特征,参比制剂的Cmax显著高于试验制剂（p〈0.01）,试验制剂给药后的tmax延迟,且吸收程度与作为标准参比制剂的市售缓释片相比无显著差异,人体相对生物利用度为103.76%.经统计学检验表明这两种制剂具有生物等效性,试验制剂具有峰谷浓度差异小、波动幅度小的特点,显示出缓释特征.
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| 关 键 词： | 酮洛芬 缓释片 药物动力学 生物利用度 |
Bioavailability of Ketoprofen Sustained-release Tablet |
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| LIN Shuo,ZHOU Jing,XU Wei,SHA Mei.Bioavailability of Ketoprofen Sustained-release Tablet[J].Journal of Quanzhou Normal College,2010,28(2):66-69. |
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| Authors: | LIN Shuo ZHOU Jing XU Wei SHA Mei |
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| Institution: | LIN Shu1,ZHOU Jing2,XU Wei1,SHA Mei1(1.School of Phamacy,Fujian College of Traditional Chinese Medicine,Fujian 350108,China,2.West China School of Phamacy,Sichuan University,Sichuan 610041,China) |
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| Abstract: | The relative bioavailability of 24 h sustained-release tablets(Test Formulation,T.F) after oral multiple-doses in 24 healthy persons were studied by HPLC with Ibuprofen as internal standard.The results show that test formulation proves to have marked sustained-release property of pharmacokinetics.The Cmax of Control Formulation(C.F) is significantly higher than that of T.F(p<0.01).The tmax of T.F is significantly longer than that of C.F and there is no significant difference in the absorption extent.The rel... |
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| Keywords: | ketoprofen sustained-release tablet pharmacokinetics bioavailability |
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