| What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor? |
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| 作者姓名： | Shi ZZ Zhang JW Zheng S |
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| 作者单位： | The Second Affiliated Hospital，Cancer Institute，School of Medicine，Zhejiang University，Hangzhou 310009，China |
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| 基金项目： | Project supported by the National Basic Research Program (973) of China (No. 2004CB518707)，the National Natureal Science Foundation of China (No. 30400521) |
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| 摘 要： | This article is to summarize the molecular and functional analysis of the gene “suppression of tumorigenicity 13” (ST13). ST13 is in fact the gene encoding Hsp70 interacting protein (Hip), a co-factor (co-chaperone) of the 70-kDa heat shock proteins (Hsc/Hsp70). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), Hip facilitates may facilitate the chaperone function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid receptors and regulators of proliferation or apoptosis. Although the nomenclature of ST13 implies a role in the suppression of tumorigenicity (ST), to date available experimental data are not sufficient to support its role in cancer development, except for the possible down-regulation of ST13 in gastric and colorectal cancers. Further investigation of this gene at the physiological level would benefit our understanding of diseases such as endocrinological disorders, cancer, and neurodegeneration commonly associated with protein misfolding.
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| 收稿时间： | 6 December 2006 |
| 修稿时间： | 10 January 2007 |
What we know about ST13, a co-factor of heat shock protein,or a tumor suppressor? |
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| Shi ZZ,Zhang JW,Zheng S.What we know about ST13, a co-factor of heat shock protein,or a tumor suppressor?[J].Journal of Zhejiang University Science,2007,8(3):170-176. |
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| Authors: | Shi Zheng-zheng Zhang Jia-wei Zheng Shu |
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| Institution: | (1) The Second Affiliated Hospital, Cancer Institute, School of Medicine, Zhejiang University, Hangzhou, 310009, China |
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| Abstract: | This article is to summarize the molecular and functional analysis of the gene “suppression on of tumorigenicity 13” (ST13).
ST13 is in fact the gene encoding Hsp70 interacting protein (Hip), a co-factor (co-chaperone) of the 70-kDa heat shock proteins
(Hsc/Hsp70). By collaborating with other positive co-factors such as Hsp40 and the Hsp70-Hsp90 organizing protein (Hop), or
competing with negative co-factors such as Bcl2-associated athanogen 1 (Bag1), Hip facilitates may facilitate the chaperone
function of Hsc/Hsp70 in protein folding and repair, and in controlling the activity of regulatory proteins such as steroid
receptors and regulators of proliferation or apoptosis. Although the nomenclature of ST13 implies a role in the suppression
of tumorigenicity (ST), to date available experimental data are not sufficient to support its role in cancer development,
except for the possible down-regulation of ST13 in gastric and colorectal cancers. Further investigation of this gene at the
physiological level would benefit our understanding of diseases such as endocrinological disorders, cancer, and neurodegeneration
commonly associated with protein misfolding.
Project supported by the National Basic Research Program (973) of China (No. 2004CB518707) and the National Natureal Science
Foundation of China (No. 30400521) |
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| Keywords: | ST13 Hip p48 Hsc/Hsp70 Heat shock protein Protein folding Steroid receptor Tumorigenicity |
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