| 中药对脑缺血再灌注损伤保护作用及机制研究进展 |
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| 引用本文： | 王树林,安芳.中药对脑缺血再灌注损伤保护作用及机制研究进展[J].河北北方学院学报(医学版),2014(3):39-48. |
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| 作者姓名： | 王树林 安芳 |
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| 作者单位： | 河北北方学院,中国张家口075000 |
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| 摘 要： | 中药对脑缺血再灌注的保护作用已成为近年来的研究热点,该文按单味中药及其提取物、中药复方和中药注射液分类综述了不同类型的中药对脑缺血再灌注损伤的保护作用机制.中药在对脑缺血再灌注的干预方面具有多层次、多靶点、多环节的作用,分别从脑缺血再灌注后的能量代谢障碍、线粒体损伤、自由基损伤、兴奋性氨基酸的毒性作用、炎症损伤及血脑屏障破坏六个方面进行阐述,并对中药的发展进行展望.
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| 关 键 词： | 中药 脑缺血再灌注损伤 机制 |
Review of the Effect of Traditional Chinese Medicine on Mechanism of Cerebral Ischemia Reperfusion Injury |
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| WANG Shu-lin,AN Fang.Review of the Effect of Traditional Chinese Medicine on Mechanism of Cerebral Ischemia Reperfusion Injury[J].Journal of Hebei North University:Medical Edition,2014(3):39-48. |
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| Authors: | WANG Shu-lin AN Fang |
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| Institution: | (Hebei North University, Zhangjiakou, 075000, China) |
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| Abstract: | Recent years,the protection of traditional Chinese medicine on Cerebral Ischemia Reperfusion Injury has become the research hotspot. The paper classified traditional Chinese medicine into single herbs and extracts ,traditional Chinese medicine and Chinese medicine injection, and summarized the protection mechanism of different traditional Chinese medicine on damage mechanism of cerebral ischemia reperfusion injury. The interference effects of traditional Chinese medicine on cerebral ischemia reperfusion injury have multi-level, multi- targeted and multi-link. The article, in several ways including metabolic disorder of energy, mitochondria damage, free radical injury, toxic effect of excitatory amino acid, inflammatory injury and disruption of the blood-brain barrier ,summarized the research developmeut and indicated the prospect of traditional Chinese medicine. |
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| Keywords: | traditional Chinese mvdicinc cvrebral ischcmia rvperfusion injury mechanisms |
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