| 运动过程中糖皮质激素受体的变化 |
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| 引用本文： | 陈佩杰,许豪文,段子才,蔡斌.运动过程中糖皮质激素受体的变化[J].上海体育学院学报,2002,26(1):33-37,42. |
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| 作者姓名： | 陈佩杰 许豪文 段子才 蔡斌 |
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| 作者单位： | 1. 上海体育学院运动人体科学实验中心,上海,200438
2. 华东师范大学体育与健康学院,上海,200062 |
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| 基金项目： | 国家体育总局立项资助课题（9601），教育部博士点基金资助课题 |
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| 摘 要： | 为探讨不同负荷量作用后的机体靶细胞GR的变化特征，本实验复制两种不同运动负荷量的动物运动模型，分别比较：(1)不同强度运动训练后大鼠心、肾胞液GR的变化；(2)7周递增运动负荷训练后大鼠肝胞液GR结合量的变化。采用竞争性蛋白结合分析法检测血浆皮质酮浓度；放射配体结合分析法测定靶细胞胞液糖皮质激素受体结合量。结果发现，运动后GR减少呈运动负荷量依赖性。对这种变化的可能机制和生理意义进行了讨论。
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| 关 键 词： | 运动 糖皮质激素受体 糖皮质激素 大鼠 |
| 文章编号： | 1000-5498(2002)01-0033-05 |
Changes of Glucocorticoid Receptor During Physical Training |
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| Chen Peijie,Xu Haowen,Duan Zhicai,Cai Bin.Changes of Glucocorticoid Receptor During Physical Training[J].Journal of Shanghai Physical Education Institute,2002,26(1):33-37,42. |
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| Authors: | Chen Peijie Xu Haowen Duan Zhicai Cai Bin |
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| Abstract: | In order to expound the effects of various training load volumes on GR, the study used two kinds of experimental models with different training load volumes and made a comparison on (1) the changes of GR in rats' kidney cytosol after various training load intensity; (2) the changes of GR binding capacity in rats' lever cytosol after the seven - week training of progressive increasing load. Meanwhile, plasma corticosterone was determined by the method of competitive binding assay, and the GR in cytosol was measured by radioligand binding assay. The results show that the decrease in glucocorticoid binding capacity after physical training was in a dependent manner of training load volume. The possible mechanism and the physiological significance of these changes are discussed in the present paper. |
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| Keywords: | sports GR glucocorticoid rat |
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