Interplay Between Inflammation and Hemostasis in Patients with Coronary Artery Disease |
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| Authors: | Medha Rajappa Binita Goswami A Balasubramanian Baidarbhi Chakraborty S Kumar |
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| Institution: | .Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India ;.Department of Biochemistry, Lady Hardinge Medical College and Associated Hospitals, New Delhi, 110001 India ;.Department of Biochemistry, Dr D Y Patil Medical College, Navi Mumbai, Maharashtra India ;.Department of Medicine, Maulana Azad Medical College and Associated Hospitals, New Delhi, India |
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| Abstract: | Coronary artery disease (CAD) is a global epidemic currently. This study was planned to evaluate markers of inflammation and hemostasis and their possible association, if any, in patients with CAD. The study was carried out in 60 patients with acute myocardial infarction (AMI) and 60 age and gender matched controls. The following parameters were assayed in all study subjects-inflammatory-interleukin (IL)-10, high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-α, fibrinogen; hemostatic-fibrinogen, fibrin D-dimer and a novel risk factor—homocysteine. Inflammatory markers (hs-CRP, TNF-α and IL-10), fibrinogen, fibrin D-dimer and homocysteine levels were significantly higher in the patients with AMI, as compared with controls. A positive correlation was observed between D-dimer and the inflammatory markers—hs-CRP and TNF-α. Upon multivariate analysis, TNF-α emerged as the best determinant of CAD in our study. Our results indicate that there is a possible interplay of inflammation and hemostasis in CAD, underlining their synergistic role in the pathogenesis of CAD. |
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| Keywords: | Acute myocardial infarction Inflammation Hemostasis Interleukin (IL)-10 High sensitivity C-reactive protein (hs-CRP) Tumor necrosis factor (TNF)-α Fibrinogen Fibrin D-dimer Homocysteine |
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