Potent antiulcerogenic activity of ethanol extract of leaf ofPiper betle Linn by antioxidative mechanism |
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| Authors: | Biswajit Majumdar Susri Ray Chaudhuri Arun Ray Sandip K Bandyopadhyay |
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| Institution: | (1) Department of Biochemistry, College of Medical Sciences, Bharatpur, Nepal;(2) Department of Biochemistry, Dr BC Roy Post Graduate Institute of Basic Medical Sciences, University College of Medicine, Calcutta University, 244B, Acharya J C Bose Road, 700 020 Kolkata |
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| Abstract: | Pretreatment of an ethanolic extract of leaf ofPiper betle linn at a dose of 200mg/kg body weight, orally administered to rats for ten consecutive days, was found to possess a significant
protective action against gastric lesions induced by indomethacin. The extract pretreatment resulted in significant increase
in superoxide dismutase (SOD) and catalase (CAT) activity, increase in mucus, hexosamine and total thiol group content, but
marked reduction in oxidatively damaged protein and peroxidised lipid levels as compared to untreated ulcerated control. The
extract was also found to possess both superoxide and hydroxyl free radical scavenging action. The present observations establish
the efficacy of the extract in prevention of experimentally induced peptic ulcer by indomethacin and antioxidant property
appears to be predominantly responsible for such cytoprotective activity in the experimental model. |
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| Keywords: | Antioxidant Antiulcer Free radical scavenger Piper betle Linn |
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