| Brain metastases of melanoma mechanisms of attack on their defence system by engineered stem cells in the microenvironment |
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| 作者姓名： | Dimitrov BD Atanassova PA Rachkova MI |
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| 作者单位： | [1]BORDAN1, Alzano Lombardo, Bergamo 24022, Italy [2]Department of Neurology, Medical University, Plovdiv 4000, Bulgaria [3]ASSON-93 Research Co., Chicago, IL 60056, USA |
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| 摘 要： | This report gives a better emphasis on the role of targeted effectors （e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone） and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.
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| 关 键 词： | 黑色素瘤 脑转移 神经系统 干细胞 胞核嘧啶脱氨基酶 |
| 收稿时间： | 2 August 2007 |
| 修稿时间： | 2007-08-022007-08-10 |
Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment |
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| Dimitrov BD,Atanassova PA,Rachkova MI.Brain metastases of melanoma mechanisms of attack on their defence system by engineered stem cells in the microenvironment[J].Journal of Zhejiang University Science,2007,8(9):609-611. |
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| Authors: | Dimitrov Borislav D Atanassova Penka A Rachkova Mariana I |
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| Institution: | (1) Alzano Lombardo, BORDANI, Bergamo, 24022, Italy;(2) Department of Neurology, Medical University, Plovdiv, 4000, Bulgaria;(3) ASSON-93 Research Co., Chicago, IL 60056, USA |
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| Abstract: | This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers. |
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| Keywords: | Melanoma Brain metastases Neural stem/progenitor cells (NSPCs) Cytosine deaminase |
| 本文献已被 维普 万方数据 PubMed SpringerLink 等数据库收录！ |
