| Science Letters： Simultaneous determination of fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate, sorbate, and saccharin in gargles by ion chromatography |
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| 作者姓名： | Zhang YZ Zhou YC Liu L Zhu Y |
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| 作者单位： | [1]Department of Stomatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China [2]Department of Stomatology, Hospital of Zhejiang University, Hangzhou 310027, China [3]Affiliated Stomatology Hospital School of Medicine, Zhejiang University, Hangzhou 310006, China [4]Department of Chemistry, Zhejiang University, Hangzhou 310028, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （Nos. 20375035 and 20527005） and the Natural Science Foundation of Zhejiang Province, China （Nos. Z404105 and Y405415） and the Science and Technology Department of Zhejiang Province, China （No. 2007C33016） |
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| 摘 要： | Simple, reliable and sensitive analytical methods to determine anticariogenic agents, preservatives, and artificial sweeteners contained in commercial gargles are necessary for evaluating their effectiveness, safety, and quality. An ion chromatography （IC） method has been described to analyze simultaneously eight anions including fluoride, chloride, sulfate, phosphate, monofluorophosphate, glycerophosphate （anticariogenic agents）, sorbate （a preservative）, and saccharin （an artificial sweetener） in gargles. In this IC system, we applied a mobile phased gradient elution with KOH, separation by IonPac AS18 columns, and suppressed conductivity detection. Optimized analytical conditions were further evaluated for accuracy. The relative standard deviations （RSDs） of the inter-day＇s retention time and peak area of all species were less than 0.938% and 8.731%, respectively, while RSDs of 5-day retention time and peak area were less than 1.265% and 8.934%, respectively. The correlation coefficients for targeted analytes ranged from 0.999 7 to 1.000 0. The spiked recoveries for the anions were 90%-102.5%. We concluded that the method can be applied for comprehensive evaluation of commercial gargles.
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| 关 键 词： | 吸收色谱学 含漱剂 阴离子 糖精 |
| 收稿时间： | 9 May 2007 |
| 修稿时间： | 2007-05-092007-05-25 |
Simultaneous determination of fluoride,chloride, sulfate,phosphate, monofluorophosphate,glycerophosphate, sorbate,and saccharin in gargles by ion chromatography |
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| Zhang YZ,Zhou YC,Liu L,Zhu Y.Simultaneous determination of fluoride,chloride, sulfate,phosphate, monofluorophosphate,glycerophosphate, sorbate,and saccharin in gargles by ion chromatography[J].Journal of Zhejiang University Science,2007,8(7):507-511. |
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| Authors: | Zhang Yan-zhen Zhou Yan-chun Liu Li Zhu Yan |
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| Institution: | (1) Department of Stomatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China;(2) Department of Stomatology, Hospital of Zhejiang University, Hangzhou, 310027, China;(3) Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China;(4) Department of Chemistry, Zhejiang University, Hangzhou, 310028, China |
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| Abstract: | Simple, reliable and sensitive analytical methods to determine anticariogenic agents, preservatives, and artificial sweeteners
contained in commercial gargles are necessary for evaluating their effectiveness, safety, and quality. An ion chromatography
(IC) method has been described to analyze simultaneously eight anions including fluoride, chloride, sulfate, phosphate, monofluorophosphate,
glycerophosphate (anticariogenic agents), sorbate (a preservative), and saccharin (an artificial sweetener) in gargles. In
this IC system, we applied a mobile phased gradient elution with KOH, separation by IonPac AS18 columns, and suppressed conductivity
detection. Optimized analytical conditions were further evaluated for accuracy. The relative standard deviations (RSDs) of
the inter-day’s retention time and peak area of all species were less than 0.938% and 8.731%, respectively, while RSDs of
5-day retention time and peak area were less than 1.265% and 8.934%, respectively. The correlation coefficients for targeted
analytes ranged from 0.999 7 to 1.000 0. The spiked recoveries for the anions were 90%∼102.5%. We concluded that the method
can be applied for comprehensive evaluation of commercial gargles.
Project supported by the National Natural Science Foundation of China (Nos. 20375035 and 20527005) and the Natural Science
Foundation of Zhejiang Province, China (Nos. Z404105 and Y405415) and the Science and Technology Department of Zhejiang Province,
China (No. 2007C33016) |
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| Keywords: | Ion chromatography Anions Gargles Monofluorophosphate Sorbate Saccharin |
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