| 运动源性自由基对大鼠肾脏线粒体游离钙和ATP合成能力的影响 |
| |
| 引用本文： | 常波.运动源性自由基对大鼠肾脏线粒体游离钙和ATP合成能力的影响[J].上海体育学院学报,2006,30(2):72-75,79. |
| |
| 作者姓名： | 常波 |
| |
| 作者单位： | 沈阳体育学院,运动生理生化教研室,辽宁,沈阳,110032 |
| |
| 摘 要： | 采用实验法,测定SD大鼠不同时相肾脏线粒体MDA、ATP合成能力和游离钙的变化。结果显示:MDA含量在运动后即刻显著性升高(P<0.05),1 h和24 h后极显著性升高(P<0.01);运动后即刻组1、h组和24 h组肾脏线粒体游离钙极显著高于对照组(P<0.01);运动后即刻组1、h组肾脏线粒体ATP合成能力极显著低于对照组(P<0.01),24 h未恢复正常(P<0.05)。提出:大鼠力竭性游泳运动可提高肾脏线粒体脂质过氧化水平,导致ATP合成能力下降,线粒体钙稳态失调;线粒体游离钙聚积可导致线粒体氧化磷酸化解偶联和肾功能异常,可能是运动性疲劳和运动性蛋白尿发生的重要原因之一。
|
| 关 键 词： | 运动源性自由基 肾脏线粒体 ATP 运动性疲劳 运动性蛋白尿 |
| 文章编号： | 1000-5498（2006）02-0072-04 |
| 收稿时间： | 2005-11-15 |
| 修稿时间： | 2005-11-152006-01-07 |
Effect of Exercise-induced Free Radicals on Mitochondrion Free Calcium and ATP Synthesis Activity in Rats' Kidney |
| |
| CHANG Bo.Effect of Exercise-induced Free Radicals on Mitochondrion Free Calcium and ATP Synthesis Activity in Rats'''' Kidney[J].Journal of Shanghai Physical Education Institute,2006,30(2):72-75,79. |
| |
| Authors: | CHANG Bo |
| |
| Abstract: | It used the method of experiment to measure the variations of kidney mitochondrion MDA,ATP synthesis ability and free calcium of SD rats in different phases.The results show that the contents of MDA remarkably increase immediately after exercise(P<0.05) and exceedingly remarkably increase both at the first hour and the twenty-fourth hour after exercise;compared with the control group,the values of exercise group's kidney mitochondrion free calcium at the first hour and the twenty-fourth hour after exercise are significantly higher(P<0.01),but its kidney mitochondrion ATP synthesis ability is far poorer immediately both after exercise and at the first hour after exercise, and can't be recovered to normal(P<0.05).It brings forward that the exhaustive swimming can lead to the increase of kidney mitochondrion lipid peroxidation level,the decrease of ATP synthesis ability and the imbalance of steady state of mitochondrion calcium;the accumulation of mitochondrion free calcium can bring about the even connexion of mitochondrion oxidation and phosphorylation and the unusualness of kidney function,which is probably one of the important reasons of exercise-induced fatigue and proteinuria. |
| |
| Keywords: | exercise-induced free radicals kidney mitochondrion ATP exercise-induced fatigue exercise-induced proteinuria |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
