| 人参皂甙Rg1和Rb1抗运动性中枢疲劳的实验研究 |
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| 引用本文： | 冯毅翀,潘华山,卞伯高,赵自明,陈楚杰.人参皂甙Rg1和Rb1抗运动性中枢疲劳的实验研究[J].军事体育进修学院学报,2010,29(3):112-115. |
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| 作者姓名： | 冯毅翀 潘华山 卞伯高 赵自明 陈楚杰 |
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| 作者单位： | 1. 广州中医药大学,广东,广州,510006
2. 广东省中医研究所,广东,广州,510095 |
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| 摘 要： | 目的：观察人参皂甙Rg1和Rb1对运动性疲劳大鼠中枢神经递质5-羟色胺（5-HT）、7氨基丁酸（GABA）、多巴胺（DA）和乙酰胆碱（Ach）含量的影响，探讨人参皂甙Rg1和Rb1对中枢神经系统的保护机制。方法：40只雄性SD大鼠随机均分为人参皂甙Rgm组（50mg／kg）、Rbl组（50mg／kg）、模型组（0．1ml／kgN．S．）和空白组（0．1ml／kgN．S．），给药组和模型组大鼠在灌胃1h后进行中等运动强度的水平跑台运动，速度为15m／min，坡度0°，跑台20min，间歇40min，在跑台20min，每天1次，连续14天。末次运动后即刻处死大鼠，迅速取下丘脑，色谱法测5-HT、GABA、DA和Ach含量。结果：人参皂甙Rg1和Rb1均能有效降低下丘脑5-Hr和GABA的含量，提高DA和Ach的含量。和人参皂甙Rg1比较，人参皂甙Rb1在降低5-HT和GAGB含量、提高DA含量方面效果更优，但在提高Ach含量方面效果相对较差。结论：人参皂甙Rg1和Rb1均能改善运动性疲劳状态下中枢神经递质紊乱的情况，从而对中枢神经系统产生保护作用，达到抗中枢疲劳的效应，但人参皂甙Rb1的效果相对更优。
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| 关 键 词： | 人参皂甙Rgl 人参皂甙Rb1 运动性中枢疲劳 |
Experimental Studies on Resisting Exercise-induced central Fatigue of Ginsenoside Rg1 and Rb1 |
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| Institution: | FENG Yi-chong PAN Hua-shan BIAN Bo-gao ZHAO ZHi-ming et al (1. Guangzhou University of Chinese Medicine, Guangzhou 510006; 2. Guangdong Institute of Chinese Medicine, Guangzhou 510095, China) |
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| Abstract: | This report describes the functional system of Ginsenoside Rg1 and Rb1 to resist exercise - induced central fatigue through the detection of contents of central neurotransmitter 5 - HT.GABA.DA and Ach in the exercise - induced fatigue rats. In the experiment, forty male SD rats were divided into 4 groups randomly： Ginsenoside Rg1 group, Rb1 group, Model group and Control group. The rats in Ginsenoside Rg1 group and Rb1 group were filled the stomach with Ginsencside Rg1 and Rb1 （50 mg/kg） once a day while the rats in Model and Control groups were filled the stomach with normal saline of the same quantity. After one hour the rats of Ginsenoside Rg1. Rb1 and Model groups did treadmill exercise with medium intensity for 20 minutes at the speed of 15 m/min and with a slope of 0 degree, and after 40 - mimute break did it for another 20minutes. Fourteen days later, contents of central neurotransmitter 5 - HT. GABA.DA and Ach had been rested. The results showed that both Ginsenoside Rg1 and Rhl could effectively reduce the contents of 5 - HT and GABA, and improve the contents of DA and Ach in hypothala- mus. As compared with Ginsenoside Rg1, Ginsenoside Rb1 demonstrated better performance in terms of reducing the content of 5 - HT.GABA and improving the content of DA, while the effect of improving the content of Ach was relatively less. We drew to the conclusion theat Ginsenoside Rg1 and Rb1 could improve the disorder of central neurotransmitter after exercise - induced fatigue in different level and different targets to achieve the desired effect of ridding exercise- induced fatiguel But the effect of Ginsenoside Rb1 is better. |
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| Keywords: | exercise - induced central Fatigue ginscncxsidc Rg1 tginsenoside Rb1 |
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