| 补充大豆多肽对过度训练大鼠肠道免疫功能的影响及其机制研究 |
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| 引用本文： | 刘军,邓玉强,金其贯.补充大豆多肽对过度训练大鼠肠道免疫功能的影响及其机制研究[J].首都体育学院学报,2011(5):474-477. |
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| 作者姓名： | 刘军 邓玉强 金其贯 |
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| 作者单位： | 南通大学体育科学学院;扬州大学体育学院; |
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| 摘 要： | 为了建立过度训练大鼠模型,探讨大豆多肽对过度训练大鼠肠道免疫功能的干预作用及其机制。将大鼠随机分为对照组、过度训练组和大豆多肽干预组,9周后,检测各组大鼠小肠组织SOD、MDA和SIgA的含量以及小肠CD4+T、CD8+T细胞数量。结果发现:与对照组比较,过度训练组大鼠小肠组织中sIgA含量、CD4+T细胞数量、CD4+/CD8+比值显著下降,小肠CD8+T细胞数量显著升高;且小肠中SOD活性显著降低,MDA含量显著升高;与过度训练组相比,SPI干预组大鼠虽然小肠组织中sIgA含量没有显著差异,但CD4+T细胞数量、CD4+T/CD8+T的比值显著升高,CD8+T细胞的数量显著降低;且小肠SOD活性显著升高,小肠MDA含量显著降低。得出结论:过度训练组大鼠小肠SIgA含量降低和脂质过氧化产物增多,是过度训练导致肠道免疫功能降低的主要机制。补充SPI后,过度训练大鼠小肠组织CD4+T与CD8+T的数量得到改善且自由基清除能力增强,可能是补充SPI防止过度训练大鼠肠道免疫功能下降的主要机制。
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| 关 键 词： | 过度训练 大豆多肽 肠道免疫 |
Research on Effects and mechanism of Soy Protein Isolate Peptide Supplementation on Intestinal Immune Function in Overtraining Rats |
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| LIU Jun,DENG Yuqiang,JIN Qiguan .School of Sports Science of Nantong University,Nantog ,China,.College of Physical Education of Yangzhou University,Yangzhou ,China..Research on Effects and mechanism of Soy Protein Isolate Peptide Supplementation on Intestinal Immune Function in Overtraining Rats[J].Journal of Capital College of Physical Education,2011(5):474-477. |
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| Authors: | LIU Jun DENG Yuqiang JIN Qiguan School of Sports Science of Nantong University Nantog China College of Physical Education of Yangzhou University Yangzhou China |
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| Institution: | LIU Jun1,DENG Yuqiang1,JIN Qiguan2 1.School of Sports Science of Nantong University,Nantog 226007,China,2.College of Physical Education of Yangzhou University,Yangzhou 225009,China. |
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| Abstract: | Objective:To establish rat model of overtraining and explore the intervention effect of soybean protein isolate peptide supplementation on the intestinal immune function of overtraining rats and its mechanism.Method:Experimental rats were randomly divided into control group,overtraining group,and soybean peptide intervention group.The content of SOD,MDA,and the SIgA and CD4+T,CD8+T quantity in small intestine were examined 9 weeks later.Results:Compared with the control group,in the small intestine tissue o... |
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| Keywords: | Overtraining Soy protein isolate peptide Intestinal immunity function |
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