| 补充胆红素对不同强度运动大鼠肝细胞凋亡的影响 |
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| 引用本文： | 徐美琴,刘琪,徐增智.补充胆红素对不同强度运动大鼠肝细胞凋亡的影响[J].吉林体育学院学报,2008,24(3):87-89. |
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| 作者姓名： | 徐美琴 刘琪 徐增智 |
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| 作者单位： | 1. 江西师范大学体育学院,江西南昌,330027
2. 浙江省上虞市职教中心体育办,浙江上虞,312300 |
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| 摘 要： | 目的：观察补充胆红素对不同强度运动造成的肝细胞凋亡的影响，为运动营养补剂的研发，减少运动性损伤提供一定的实验依据。方法：以53只健康雄性SD大鼠为研究对象，随机分成五个组，即安静对照组、中等强度运动训练组、中等强度运动训练补胆红素组、大强度运动训练组、大强度运动训练补胆红素组，力竭运动组、力竭运动补胆红素组、通过流式细胞仪检测技术检测强抗氧化剂对肝细胞凋亡的影响。同时观察与分析肝组织SOD的活性与MDA的含量。结果表明：力竭运动和大强度运动训练能诱导大鼠肝细胞凋亡增加；补充胆红素使其凋亡率下降，其原因与补充胆红素能提高机体抗氧化应激有关。
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| 关 键 词： | 细胞凋亡 补胆红素 超氧化物歧化酶 丙二醛 肝细胞 |
Effects of Bilirubin Intake on Apoptosis in Hepatocyte of Training Rats |
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| Xu Meiqin,Liu Qi,Xu Zengzhi.Effects of Bilirubin Intake on Apoptosis in Hepatocyte of Training Rats[J].Journal of Jilin Institute of Physical Education,2008,24(3):87-89. |
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| Authors: | Xu Meiqin Liu Qi Xu Zengzhi |
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| Institution: | Xu Meiqin, Liu Qi, Xu Zengzhi ( 1. Physical Education Department, Jiangxi Normal University, Nanchang,330027, China; 2. P.E. Office of Vocational Education,Shangyu,312300,Zhejiang, China) |
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| Abstract: | Objectives:To observe effecting of bilirubin intake on apoptosis in hepatocyte of training rats,it offeres the experimental basis for developing exercise-nutrition food reducing movement damage.Research methods:regarded healthy male SD rats of 53 as the research objects,divided into seven groups at random,namely quiet to contrast group,middle intensity training group,middle intensity training intake bilirubin group,large intensity training group,large intensity training intake bilirubin group,strength exhaust sport group,strength exhaust sport intake bilirubin group,adopted flow cytometer detection technique to observe supplementary strong antioxidant bilirubin result in hepatocyte apoptosisphenomenon,The concentration of Superoxide dismutase(SOD),malondialdehyde(MDA) were measured at the time.Result:Bilirubin intake to make hepatocyte apoptosis decrease,Superoxide dismutase(SOD) slightly rise,Malondialdehyde(MDA) quantity reduce. |
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| Keywords: | apoptosis bilirubin intake superoxide dismutase(SOD) malondialdehyde(MDA) hepatocyte |
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