| 运动疲劳应激大鼠杏仁体核簇神经元中一氧化氮合酶的表达 |
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| 引用本文： | 刘鸿宇,于芳,王琳,耿绍玮,李中华.运动疲劳应激大鼠杏仁体核簇神经元中一氧化氮合酶的表达[J].成都体育学院学报,2005,31(1):93-96. |
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| 作者姓名： | 刘鸿宇 于芳 王琳 耿绍玮 李中华 |
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| 作者单位： | 中北大学运动人体科学实验中心,山西,太原,030051 |
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| 基金项目： | 中北大学校科研和教改项目 |
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| 摘 要： | 方法:经4周大强度游泳训练制成大鼠运动疲劳模型,用ABC免疫组织化学方法显示杏仁皮质前核(Aco)、杏仁内侧核(Me)、杏仁中央核(Ce)、杏仁基底内侧核(Bm)、杏仁基底外侧核(BLN)和杏仁外侧核(La)中的nNOS阳性神经元,用图像处理半定量方法对nNOS阳性神经元的数量、面积和灰度进行分析.结果:疲劳组大鼠Ce中nNOS阳性神经元的灰度值明显小于对照组,Bm中nNOS阳性神经元数量、面积和灰度均大于对照组.结论:疲劳应激可使大鼠杏仁体核簇神经元中nNOS的表达发生改变,杏仁体核簇nNOS阳性神经元参与了运动性中枢疲劳的形成,其机理可能与杏仁体核簇神经元对应激反应的心理、行为、内分泌调节以及NO的神经毒性有关.
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| 关 键 词： | 应激 运动性疲劳 杏仁体核 大鼠 |
| 文章编号： | 1001-9154(2005)01-0093-04 |
| 修稿时间： | 2004年11月24日 |
Expression of Nitric Oxide Synthase (NOS) in Amygdaloid Nuclei of Rats under Stress of Exercise -Induced Fatigue |
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| LIU Hongyu,et al.Expression of Nitric Oxide Synthase (NOS) in Amygdaloid Nuclei of Rats under Stress of Exercise -Induced Fatigue[J].Journal of Chengdu Physical Education Institute,2005,31(1):93-96. |
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| Authors: | LIU Hongyu |
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| Abstract: | Methods: After 4 weeks swimming exercise with high intensity, the nNOS positive neurons were shown in amygdaloid nuclei, by using ABC immunohistochemistry integrating with image pattern semiquantitative analysis (neuron number, area and gray degree). Result: A significant decrease of nNOS positive neurons in anterior cortical amygdaloid nucleus (Aco), medial amygdaloid nucleus(Me), central amygdaloid nucleus (Ce) in the number and area in fatigue group , and a significant decrease of nNOS positive neurons in Ce in gray degree in fatigue group, and a significant increase of nNOS positive neurons in Bm in the number, area and gray degree in fatigue group, and a significant increase of nNOS positive neurons in BLN in the number and gray degree in fatigue group, and a significant increase of nNOS positive neurons in La in the area and gray degree in fatigue group. Conclusion: stress of exercise-induced fatigue can induce changed expression of nNOS in amygdaloid nuclei which were involved in forming of exercise-induced central fatigue, due to the psychological, behavioral, and endocrine regulation of amygdaloid nuclei on stress, as well as NO neurotoxicity. |
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| Keywords: | nNOS |
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