| 超速驱动对大鼠离体心脏影响的研究 |
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| 引用本文： | 李岩,颜辉.超速驱动对大鼠离体心脏影响的研究[J].成都体育学院学报,2004,30(4):71-73. |
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| 作者姓名： | 李岩 颜辉 |
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| 作者单位： | 山东烟台师范学院体育学院,山东,烟台,264000 |
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| 摘 要： | 为进一步研究疲劳状态下心脏的功能变化,以大鼠离体心脏为研究对象,采用Langendorff灌流装置,对离体心脏施加一定频率和强度的电驱动.研究表明,一定时间的超速驱动后,离体心脏出现明显缺血症状,心肌乳酸脱氢酶漏出增多,谷胱甘肽过氧化物酶活性降低,丙二醛含量增多,心肌组织和线粒体发生钙超载.
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| 关 键 词： | 离体心脏 疲劳 Langendorff灌流 超速驱动 缺氧缺血 |
| 文章编号： | 1001-9154(2004)04-0071-03 |
| 修稿时间： | 2004年4月15日 |
Study On The Impact Of Overdrive On The Isolated Rat Heart |
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| LI Yan,et al.Study On The Impact Of Overdrive On The Isolated Rat Heart[J].Journal of Chengdu Physical Education Institute,2004,30(4):71-73. |
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| Authors: | LI Yan |
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| Abstract: | To research the change of the heart function under fatigue condition, rat heart was isolated and put on a langendorff perfusion device. Then, the isolated hearts was stimulated by electric current with certain frequency and strength. The result indicated that after a period of overdrive, the hearts expressed hypoxia and ischemia symptom obviously, the level of LDH in the perfusion solution increased, activity of GSH-Px decrease, the content of MDA is elevated and calcium overload was found in both myocardium and mitochondrion. |
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| Keywords: | isolated heart fatigue langendorff perfusion over drive hypoxia and ischemia |
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