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| IRS1、Akt、FOXO1在少肌症发生及其运动性缓解中的作用 | |
| 引用本文： | 王今越,王小虹,冯维斗.IRS1、Akt、FOXO1在少肌症发生及其运动性缓解中的作用[J].成都体育学院学报,2012,38(7):86-91. |
| 作者姓名： | 王今越 王小虹 冯维斗 |
| 作者单位： | 1. 佛山大学体育学院,广东佛山,528000 2. 东北师范大学体育学院,吉林长春,130026 3. 吉林省体育科学研究所,吉林长春,130022 |
| 基金项目： | 吉林省自然基金发展计划，佛山体育科研计划，吉林体育科研计划 |
| 摘 要： | 目的:探索IRS1、Akt、FOXO1在少肌症的发生及运动缓解中的作用。方法:24只雄性SD大鼠分为3组,C组(青年安静组)、S组(40d D-半乳糖注射致衰组)、E组(40d D-半乳糖注射衰老+6wk跑台运动组)。检测C、S、E组大鼠体重、腓肠肌的质量、Phospho-IRS1(Ser307)、IRS1、Phospho-Akt(Ser473)、Akt、核内FOXO1、MAFbx mRNA、MuRF1 mRNA、MyoD mRNA、MyoG mR-NA。结果:与C组相比,S组大鼠腓肠肌/体重降低、Phospho-IRS1(Ser307)升高、IRS1、Phospho-Akt(Ser473)、Akt下降,FOXO1、MAFbx mRNA、MuRF1mRNA、MyoD mRNA、MyoG mRNA升高,与S组相比,E组大鼠上述除MyoD mRNA、MyoG mRNA(均上调)外的指标均发生相反变化。结论:衰老肌肉IRS1/Akt/FOXO1通路的生肌信号抑制、分解信号增强,通路可能通过提高(泛素蛋白酶体途径)分解代谢而非降低(生肌因子途径)合成代谢介导了少肌症发生,长期规律运动引起衰老肌肉IRS1/Akt/FOXO1通路生肌信号增强、分解信号抑制,通路可能通过抑制(泛素蛋白酶体途径)分解代谢及提高(生肌因子途径)合成代谢拮抗少肌症,缓解肌肉流失。 |
| 关 键 词： | 运动 衰老 少肌症 IRS1 Akt FOXO1 |
Effect of IRS1, Akt, FOXO1 on Occurrence of Sarcopenia and its Exercise-induced Remission |
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| Institution: | WANG Jin-yue,et al(1.Foshan University,Foshan Guangdong 528000;2.Northeast Normal University,Changchun Jilin 130026) |
| Abstract: | Purpose: to explore the effect of IRS1,Akt,FOXO1 on the occurrence of sarcopenia and its exercise remission.Methods: 24 males SD rats are divided into three groups,Group C(young quiet group),Group S(40 d D-galactose injection induced failure group),Group E(40 d D-galactose injection induced failure + 6wk treadmill exercise group).A detection is conducted of the weight,gastrocnemius quality of C,S,E rats,Phospho-IRS1(Ser307),IRS1,Phospho-Akt(Ser473),Akt,the nuclear FOXO1,MAFbx mRNA,MuRF1 mRNA,MyoD mRNA,MyoG mRNA.Results: compared with Group C,the gastrocnemius/weight of rats in Group S decrease,Phospho-IRS1(Ser307) FOXO1、MAFbx mRNA、MuRF1mRNA 、MyoD mRNA、MyoG mRNA increase;compared with Group S,the indexes of rats in Group E(except the above MyoD mRNA、MyoG mRNA) change correspondingly.Conclusions: the myogenic signal of the passage of aging muscle IRS1 / Akt/FOXO1 is suppressed,the decomposition signal increases,the passage can mediate the occurrence of sarcopenia by improving catabolism instead of reducing anabolism.Long and regular exercises can lead to the increase of myogenic signal of the passage of the aging muscle and the suppression of the decomposition signal.The passage can resist sarcopenia and relieve muscle loss by suppressing catabolism and increasing anabolism. |
| Keywords: | movement Aging Less muscle disease IRS1 Akt FOXO1 |
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