| 基于一氧化氮和天然抗氧化剂的新配方的心肌保护作用 |
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| 作者姓名： | 冯润 王红云 赵保路 陆忠兵 |
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| 作者单位： | 1.中国科学院大学生命科学学院, 北京 100049;2.中国科学院生物物理研究所, 北京 100101 |
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| 基金项目： | 国家自然科学基金（81270319）和中国科学院科教融合项目（KJRH2015-005）资助 |
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| 摘 要： | 研究一种以一氧化氮合酶底物L-精氨酸和山楂提取物、虾青素和知母宁等天然抗氧化剂为主要成分的配方产品ZPF1对心肌的保护作用.发现，ZPF1显著促进大鼠心肌细胞H9C2细胞增殖，减少苯肾上腺素诱导的活性氧.在异丙肾上腺素（ISO）诱导小鼠心肌肥厚的模型中，喂食100 mg/（kg·d）的ZPF1显著抑制ISO引起的心肌肥厚和功能失常，其机制与上调SERCA2a蛋白有关.这些事实说明，一氧化氮和天然抗氧化剂的组合产品ZPF1对心力衰竭有较好的防治作用.
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| 关 键 词： | 一氧化氮 天然抗氧化剂 心肌肥厚 |
| 收稿时间： | 2015-12-02 |
| 修稿时间： | 2016-03-09 |
Protective effect of a new formula based on nitric oxide and natural antioxidants on myocardium |
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| Authors: | FENG Run WANG Hongyun ZHAO Baolu LU Zhongbing |
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| Institution: | 1.College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China;2.Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | ZPF1 is a new formula that is composed of L-Arg and several natural antioxidants. In this study, the cardioprotective effect of ZPF1 has been investigated. It was found that ZPF1 promotes H9C2 cell growth and decreases intracellular ROS level in phenylephrine-treated cells. ZPF1 also attenuates isoprenaline-induced cardiac hypertrophy and dysfunction in mice, which is due to SERCA2a up-regulation.Our findings suggest that the combination of NO and natural antioxidants serves possible therapeutic intervention against heart failure. |
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| Keywords: | nitric oxide (NO) natural antioxidants myocardial hypertrophy |
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