| 过度训练对大鼠肠道sIgA和血浆内毒素含量的影响以及谷氨酰胺的干预作用 |
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| 引用本文： | 金其贯,王海军,刘丽,王永亮.过度训练对大鼠肠道sIgA和血浆内毒素含量的影响以及谷氨酰胺的干预作用[J].北京体育大学学报,2009,32(3). |
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| 作者姓名： | 金其贯 王海军 刘丽 王永亮 |
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| 作者单位： | 金其贯,刘丽,王永亮,JIN Qi-guan,LIU Li,WANG Yong-liang(扬州大学体育学院,江苏扬州,225009);王海军,WANG Hai-jun(南通航运职业技术学院,江苏南通,226010)
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| 基金项目： | 扬州大学科技创新培育基金 |
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| 摘 要： | 目的:探讨过度训练对肠道slgA和血浆内毒素含量的影响及其谷氨酰胺的干预作用和机制.方法:实验大鼠随机分为对照组、过度训练组、谷氨酰胺干预组,过度训练组大鼠进行每周6次,共9周的力竭性运动训练,谷氨酰胺干预组大鼠在大负荷运动之前按1.5 g/kgBW剂量补充谷氨酰胺,9周后,检测各组大鼠小肠slgA、Gln、MDA的含量及SOD活性.结果:1)与对照组比较,过度训练组大鼠小肠sIgA含量显著下降;且小肠SOD活性、Gln含量显著下降,MDA含量显著升高.2)与过度训练组相比,Gln干预组小肠slgA和Gln的含显著升高,虽然SOD活性没有显著性变化,大鼠小肠组织中MDA含量显著降低.结论:1)过度训练导致大鼠肠道体液免疫功能显著下降;过度训练时大鼠肠道Gln水平下降和自由基代谢的增强,可能是过度训练引起肠道免疫功能降低的主要机制.2)补充Gln可改善长期大负荷运动训练大鼠肠道体液免疫功能;而Gln的补充可使大负荷训练大鼠肠道Gln含量升高和氧自由基生成减少,可能是Gln补充防止大负荷训练大鼠肠道体液免疫功能下降的主要机制.
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| 关 键 词： | 过度训练 谷氨酰胺 肠道体液免疫 肠道slgA 血浆内毒素 |
Effect of Overtraining on Intestinal sIgA and Plasma Endotoxins Concentration in Rats and Intervention of Glutamine Supplementation |
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| JIN Qi-guan,WANG Hai-jun,LIU Li,WANG Yong-liang.Effect of Overtraining on Intestinal sIgA and Plasma Endotoxins Concentration in Rats and Intervention of Glutamine Supplementation[J].Journal of Beijing Sport University,2009,32(3). |
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| Authors: | JIN Qi-guan WANG Hai-jun LIU Li WANG Yong-liang |
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| Institution: | 1.Physical Education College;Yangzhou University;Yangzhou 225009;Jiangsu China;2.Nantong Shipping College;Nantong 226010;Jiangsu China |
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| Abstract: | Objective: To explore the effect of overtraining on sIgA and plasma endotoxins concentration in rats and the intervention effect of glutamine and its mechanisms.Method: Experimental rats are randomly divided into control group,overtraining group and glutamine intervention group.The rats in overtraining group are carrying on exhaustive training for 9 weeks,6 times/week.The rats in glutamine intervention group is supplemented Gln with 1.5g /kgBW dosage before heavy training.9 weeks later,intestinal sIgA,Gln,M... |
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| Keywords: | overtraining glutamine intestinal humoral immunity intestinal sIgA plasma endotoxins |
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