| 不同运动负荷对大鼠心肌超微结构及一氧化氮与一氧化氮合酶的影响 |
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| 引用本文： | 孙红梅.不同运动负荷对大鼠心肌超微结构及一氧化氮与一氧化氮合酶的影响[J].北京体育大学学报,2008,31(7). |
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| 作者姓名： | 孙红梅 |
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| 作者单位： | 山东体育学院日照校区基础理论系,山东,日照,276826 |
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| 基金项目： | 2006年第29届FIMS世界运动医学大会口头报告 |
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| 摘 要： | 目的:采用大鼠8周递增负荷游泳训练模型,探讨不同负荷运动对大鼠心肌超微结构的影响,以及引起心肌、血清中NO、NOS变化的原因。方法:纯种健康雄性SD大鼠36只,按体重随机分为对照组、适宜负荷组、过度负荷组,观察8周游泳训练后大鼠心肌超微结构及心肌、血清中NO、NOS的变化。结论:1)不同负荷的游泳训练可以提高大鼠心肌、血清中NO的含量;2)适宜负荷的游泳训练可以提高大鼠心肌、血清中cNOS活性,改善大鼠心肌超微结构,提高心血管系统的功能,推测适宜负荷的游泳训练提高大鼠心肌、血清中cNOS的活性可能有利于大鼠心肌超微结构的改善;3)长时间过度负荷的游泳训练可以使大鼠心肌、血清中iNOS活性升高,大鼠心肌超微结构损伤,使心血管系统功能下降,推测过度负荷的游泳训练引起的大鼠心肌超微结构损伤可能与大鼠心肌、血清中iNOS活性的升高有关。
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| 关 键 词： | 递增负荷 鼠 一氧化氮 一氧化氮合酶 心肌超微结构 |
The Influence of Different Workloads on Rat s' Myocardial Microstructure and Nitric Oxide and Nitric Oxide Synthesis enzyme |
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| SUN Hong-mei.The Influence of Different Workloads on Rat s'' Myocardial Microstructure and Nitric Oxide and Nitric Oxide Synthesis enzyme[J].Journal of Beijing Sport University,2008,31(7). |
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| Authors: | SUN Hong-mei |
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| Abstract: | Adapting rat swimming model with increasing workload for 8 weeks,this study discusses the influence of different workloads on rat s' myocardial microstructure and the possible reasons for the change of NO,NOS in blood serum and cardiac muscle,and speculated that there is some relationship between rats' myocardial microstructure and the content of NO and the activity of NOS,which can provide certain basis for heart's accommodation during exercise training.In this study we can conclude that 1) the content of NO in rats' blood serum and cardiac muscle can be improved by different workload swimming training.2) Moderate workload swimming training can increase the activity of cNOS in rat's blood serum and cardiac muscle,which probably benefits the rat's myocardial microstructure and improves the function of rats' cardiovascular system.3) Overload swimming training lasting long hours can increase the activity of iNOS in rats' blood serum and cardiac muscle,which probably spoils the rats' myocardial microstructure and causes the function of rats' cardiovascular system to decrease. |
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| Keywords: | increasing workload rats nitric oxide nitric oxide synthesis enzyme myocardial microstructure |
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