| 不同区域脑组织对运动诱导氧化应激和DNA损伤的反应 |
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| 引用本文： | 唐光旭,赵丽,吕媛媛,李岩,何凌骁.不同区域脑组织对运动诱导氧化应激和DNA损伤的反应[J].北京体育大学学报,2010(12). |
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| 作者姓名： | 唐光旭 赵丽 吕媛媛 李岩 何凌骁 |
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| 作者单位： | 河西学院体育系;北京体育大学; |
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| 基金项目： | 教育部博士学科点专项科研基金新教师基金(200800431001); 国家体育总局课题(10B029) |
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| 摘 要： | 目的:观察8周规律游泳运动对脑组织不同区域的氧化应激体系和DNA损伤的影响。方法:符合实验条件的24只雄性SD大鼠随机分为两组:安静组、递增负荷8周规律游泳组。采用免疫组化染色和生物化学检测方法,观察8周规律游泳运动对脑组织不同区域丙二醛(MDA)含量和谷胱甘肽过氧化物酶(GSH-PX)活性以及8-羟基-2’-脱氧鸟苷(8-OHdG)表达情况的影响。结果:8周规律游泳可以使大鼠海马组织的GSH-PX活性增加,同时MDA含量降低(p<0.05);但皮层GSH-PX活性及MDA含量与安静组相比无统计学意义;DNA损伤的产物8-OHdG表达在皮层和海马组织中与安静组之间无差别。结论:规律游泳运动可增加海马组织GSH-PX活性,对皮层GSH-PX活性无影响;运动对皮层和海马组织GSH-PX活性的影响不同,但并没有增加皮层的DNA损伤,可能是氧化应激过程中不同脑区的调节机制不同。
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| 关 键 词： | 运动 8-羟基-2’-脱氧鸟苷 氧化应激 皮层 海马 |
Different Response in Rat Special Brain Regions to the Oxidative Stress and DNA Damage Triggered by Exercises |
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| TANG Guang-xu,ZHAO Li,LV Yuan-yuan,LI Yan,HE Ling-xiao.Different Response in Rat Special Brain Regions to the Oxidative Stress and DNA Damage Triggered by Exercises[J].Journal of Beijing Sport University,2010(12). |
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| Authors: | TANG Guang-xu ZHAO Li LV Yuan-yuan LI Yan HE Ling-xiao |
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| Institution: | TANG Guang-xu1,ZHAO Li2,LV Yuan-yuan2,LI Yan2,HE Ling-xiao2(1.Department of Physical Education,Hexi University,Zhangye 734000,Gansu China,2.Beijing Sport University,Beijing 100084 China) |
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| Abstract: | Objective:To investigate the effects of 8 weeks swimming training on oxidative stress system and DNA damage in different brain region in rats.Method: The male SD rats were divided into the following categories:Twenty-four rats were placed in a tank for swimming twice a day for 90min,in total 8 weeks each.And rat special brain levels of MDA and GPx were measured.Furthermore,the expression of 8-OHdG was detected with immunohistochemical method.Result: 8 weeks swimming training resulted in increased GPx activi... |
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| Keywords: | exercise 8-OHdG oxidative stress cortex hippocampus |
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