| 间歇性负重游泳训练对大鼠杏仁基底外侧核(BLA)c-fos蛋白表达的影响 |
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| 引用本文： | 于芳,张安民,王根深,汪晓阳.间歇性负重游泳训练对大鼠杏仁基底外侧核(BLA)c-fos蛋白表达的影响[J].北京体育大学学报,2008,31(10). |
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| 作者姓名： | 于芳 张安民 王根深 汪晓阳 |
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| 作者单位： | 中北大学运动人体科学实验中心，烟台大学体育学院，山西大学体育学院 |
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| 基金项目： | 国家自然科学基金资助课题;项目 |
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| 摘 要： | 目的:观察间歇性负重游泳训练后大鼠杏仁基底外侧核(BLA)内c-fos蛋白表达的变化,探讨间歇性游泳训练对c-fos蛋白表达的诱导机制。方法:建立大鼠间歇性负重游泳训练模型,用ABC免疫组织化学方法检测训练后即刻、0.51、h2、h4、h大鼠BLA内c-fos蛋白表达状况,并通过图像分析系统和统计学软件进行图像和数据分析。结果:对照组大鼠BLA内c-fos阳性神经元少量散在分布;模型组明显增多,且随着时间的增长呈上升趋势(0.5 h<1 h<2 h),2 h达到峰值,与对照组相比具有非常显著性差异(P<0.01);然后逐渐下降。结论:间歇性负重游泳训练可引起大鼠BLA中c-fos蛋白表达上调,且具有一定的时效性,其机制可能与间歇运动能引起神经细胞内钙离子浓度变化有关。
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| 关 键 词： | 间歇训练 杏仁基底外侧核 c-fos蛋白 大鼠 |
The Influence of Intermittent Swimming Exercise on the Expression of C-fos Protein in Basolateral Nucleus of Rat Amygdale |
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| YU Fang,ZHANG An-ming,WANG Geng-shen,WANG Xiao-yang.The Influence of Intermittent Swimming Exercise on the Expression of C-fos Protein in Basolateral Nucleus of Rat Amygdale[J].Journal of Beijing Sport University,2008,31(10). |
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| Authors: | YU Fang ZHANG An-ming WANG Geng-shen WANG Xiao-yang |
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| Institution: | YU Fang1,ZHANG An-ming2,WANG Geng-shen3,WANG Xiao-yang3 |
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| Abstract: | Objective To investigate the mechanism of the expression of cfos protein by observing the changing tendency of c-fos protein in basolateral nucleus of rat amygdale(BLA) after intermittent swimming exercise.Methods: To establish the intermittent swimming exercise models,and detect the expression of c-fos protein in BLA at the moments of 0 h,0.5 h,1 h,2 h,4 h after exercise by immunohistochemical SABC method,then analyze the image and data by image analyzing system and statistic software.Results: Several Fos neurons of control group distribute in the BLA dispersively while the swimming groups express significantly higher,and increases progressively with time(0.5 h<1 h<2 h),the peak of Fos neurons happened at 2 h,and appears significant difference as compared with the control group(P<0.01);then descends regularly.Conclusion: Intermittent swimming exercise raises the expression of c-fos protein in BLA,and has a certain timeliness.The mechanism has deal with the change of the intracellular calcium concentration at nerve cells. |
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| Keywords: | intermittent exercise basolateral nucleus of amygdale(BLA) c-fos protein rat |
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