| 低氧运动对骨骼肌胰岛素受体亲和力的影响 |
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| 引用本文： | 刘霞,曾凡星,叶鸣.低氧运动对骨骼肌胰岛素受体亲和力的影响[J].北京体育大学学报,2007,30(5):633-635,638. |
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| 作者姓名： | 刘霞 曾凡星 叶鸣 |
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| 作者单位： | 1. 北京体育大学,北京,100084
2. 首都体育学院运动生理教研室,北京,100088 |
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| 摘 要： | 目的:观察低氧运动对骨骼肌胰岛素受体亲和力的影响.方法:各组大鼠经过跑台运动和低氧暴露后,用受体放射性配基结合分析法(RBA)测定大鼠骨骼肌胰岛素受体亲和力.结果:1 d急性低氧运动后,常氧运动组和高住低训组骨骼肌胰岛素受体高亲和力常数(KD1)显著性增加(P＜0.05),高亲和力受体结合容量(RT1)、低亲和力常数(KD2)和受体结合容量(RT2),在各组之间无显著性差异(P＞0.05).28 d低氧运动后,各组之间高亲和力受体常数(KD1)、受体结合容量(RT1)无显著性差异(P＞0.05),但低氧暴露组、常氧运动组及高住低训组的低亲和力受体常数(KD2)和受体结合容量(RT2)均有非常显著性增加(P＜0.01).结论:低氧和/或运动对胰岛素低亲和力受体的影响更为显著,使胰岛素受体亲和力下降,但同时使胰岛素受体密度显著增加,从而增强胰岛素对低氧和/或运动的反应能力.
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| 关 键 词： | 低氧运动 胰岛素受体 亲和力常数 结合容量 低氧运动 大鼠骨骼肌 胰岛素 受体亲和力 影响 Skeletal Muscles Insulin Receptor Affinity Hypoxia 反应能力 增强 受体密度 低亲和力受体 力常数 无显著性差异 结合容量 高亲和力 高住低训 常氧 运动后 |
| 文章编号： | 1007-3612(2007)05-0633-04 |
| 修稿时间： | 2006年3月21日 |
The Influences of Hypoxia Exercises on the Affinity of Insulin Receptor of Skeletal Muscles |
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| LIU Xia,ZENG Fan-xing,YE Ming.The Influences of Hypoxia Exercises on the Affinity of Insulin Receptor of Skeletal Muscles[J].Journal of Beijing Sport University,2007,30(5):633-635,638. |
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| Authors: | LIU Xia ZENG Fan-xing YE Ming |
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| Abstract: | To observe the influences of hypoxia exercises on the affinity of insulin receptor of skeletal muscles,with RBA,we measure the affinity of insulin receptor of skeletal muscles in rats.After one day hypoxia exercises,the KD1 of exercise group and hypoxia exercise group are obviously increased(P<0.05),but the RT1,KD2 and RT2 have no significant differences with the control group(P>0.05).After 28 days hypoxia exercises,the KD1,RT1 of hypoxia exposure exercise and hypoxia exercise group have no significant differences with the control group,too(P>0.05).But the KD2,RT2 of hypoxia exposure exercise and hypoxia exercise group are obviously increased(P<0.01).The effects of hypoxia exercises on the low affinity of insulin receptor are more noticeable.Hypoxia exercises decrease the affinity of insulin receptor,but obviously increase the number of insulin receptors and the reaction ability of insulin to hypoxia exercises. |
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| Keywords: | hypoxia exercises insulin receptor KD RT |
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