| 不同负荷游泳训练及补硒对衰老大鼠心肌抗氧化能力及血清GOT的影响 |
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| 引用本文： | 史亚丽,辛晓林,王昌留.不同负荷游泳训练及补硒对衰老大鼠心肌抗氧化能力及血清GOT的影响[J].北京体育大学学报,2002,25(5):636-637. |
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| 作者姓名： | 史亚丽 辛晓林 王昌留 |
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| 作者单位： | 烟台师范学院,山东,烟台,264025 |
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| 摘 要： | 老年wister 大鼠随机分为5组:正常对照组;补硒组(0.5mg/kg);有氧运动+补硒组;有氧运动组;大强度运动组,观察5周.结果表明:补硒组、补硒+有氧运动组、心肌脂质过氧化水平明显下降,同时GSH-Px活性明显升高,CuZn-SOD活性变化不明显.有氧运动组CuZn-SOD酶活性明显上升.GSH-PX活性变化不明显.大强度运动组脂质过氧化水平明显升高,CuZn-SOD酶及GSH-Px活性有下降趋势,血清GOT活性明显升高.补硒组、有氧运动组GOT变化不明显.表明有氧运动可提高心肌细胞抗氧化酶活性,从而有效防止自由基损伤,延缓器官衰老,补硒同时进行有氧运动效果更好.大强度运动由于自由基大量生成,破坏了抗氧化酶活性,产生自由基损伤导致心肌细胞破损.
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| 关 键 词： | 补硒 心肌 抗氧化 血清GOT |
| 文章编号： | 1007-3612(2002)05-0636-02 |
| 修稿时间： | 2002年1月21日 |
Effects of Swimming Training with Different Loads and Selenium Supplement on Antioxidant Capacity and Serum GOT in Cardiac Muscles of Senile Rats |
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| SHI Li-ya,XIN Xiao-lin,WANG Chang-liu.Effects of Swimming Training with Different Loads and Selenium Supplement on Antioxidant Capacity and Serum GOT in Cardiac Muscles of Senile Rats[J].Journal of Beijing Sport University,2002,25(5):636-637. |
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| Authors: | SHI Li-ya XIN Xiao-lin WANG Chang-liu |
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| Abstract: | The senile wister rats were randomly divided into 5 groups - the control group, the selenium supplement(0.5mg/kg)group, the aerobic exercise + selenium supplement group, the aerobic exercise group and the high-intensive exercise group. They were observed for 5 weeks. The results showed that the lipin peroxide level of the cardiac muscles dropped remarkably in the selenium supplement and the aerobic exercise + selenium supplement group. Meanwhile, the activity of GSH-Px increased obviously and the CuZn-SOD activity didn't change remarkably. In the aerobic exercise group the CuZn-SOD activity increased obviously, and the activity of GSH-Px didn't change remarkably. In the high-intensity exercise group the lipin peroxide level raised remarkably and the activities of CuZn-SOD and GSH-Px tended to decline. The change of serum GOT activity was remarkable. The changes of GOT were not obvious in the selenium supplement group and the aerobic exercise group. It was indicated that the activity of the antioxidant enzyme of cardiac muscle cells is able to increase through aerobic exercises so that the free radical injury is prevented effectively and the senescence of organs is delayed. There are better effects in doing aerobic exercises at the same time with the selenium supplement. During high-intensity exercise due to the production of a great quantity of free radical, the activities of the antioxidant enzymes are destroyed so as to bring about the free radical injury, leading to the destruction of cardiac muscle cells. |
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| Keywords: | selenium supplement cardiac muscle antioxidant action serum GOT |
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